New developments in anti-malarial target candidate and product profiles
JN Burrows, S Duparc, WE Gutteridge… - Malaria journal, 2017 - Springer
A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …
renewed focus on malaria elimination and eradication. Changes in the way new anti …
Glucose-6-phosphate dehydrogenase deficiency
G6PD was discovered and biochemically characterized in 1932 by Otto Warburg and Walter
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …
[PDF][PDF] Glucose-6-phosphate dehydrogenase deficiency
L Luzzatto, A Mehta, T Vulliamy - The metabolic and molecular …, 2001 - thebloodproject.com
G6PD was discovered and biochemically characterized in 1932 by Otto Warburg and Walter
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …
G6 PD deficiency: a classic example of pharmacogenetics with on‐going clinical implications
L Luzzatto, E Seneca - British journal of haematology, 2014 - Wiley Online Library
That primaquine and other drugs can trigger acute haemolytic anaemia in subjects who
have an inherited mutation of the glucose 6‐phosphate dehydrogenase (G6 PD) gene has …
have an inherited mutation of the glucose 6‐phosphate dehydrogenase (G6 PD) gene has …
Primaquine-induced haemolysis in females heterozygous for G6PD deficiency
Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency.
Understanding the relationship between G6PD genotype and the phenotypic expression of …
Understanding the relationship between G6PD genotype and the phenotypic expression of …
The state of the art in anti-malarial drug discovery and development
J N. Burrows, K Chibale… - Current topics in medicinal …, 2011 - benthamdirect.com
Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet,
unfortunately, apart from artemisinin combination therapies there are relatively few effective …
unfortunately, apart from artemisinin combination therapies there are relatively few effective …
A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial
Four Artemisinin-Based Combinations (4ABC) … - PLoS …, 2011 - journals.plos.org
Background Artemisinin-based combination therapies (ACTs) are the mainstay for the
management of uncomplicated malaria cases. However, up-to-date data able to assist sub …
management of uncomplicated malaria cases. However, up-to-date data able to assist sub …
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase–deficient children receiving dapsone
A Pamba, ND Richardson, N Carter… - Blood, The Journal …, 2012 - ashpublications.org
Drug-induced acute hemolytic anemia led to the discovery of G6PD deficiency. However,
most clinical data are from isolated case reports. In 2 clinical trials of antimalarial …
most clinical data are from isolated case reports. In 2 clinical trials of antimalarial …
Malaria: an update on current chemotherapy
BJ Visser, M van Vugt, MP Grobusch - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Chemotherapy of malaria has become a rapidly changing field. Less than two
decades ago, treatment regimens were increasingly bound to fail due to emerging drug …
decades ago, treatment regimens were increasingly bound to fail due to emerging drug …
Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Mali: a systematic review and meta-analysis
FO Maiga, M Wele, SM Toure, M Keita, CO Tangara… - Malaria Journal, 2021 - Springer
Background Artemisinin-based combination therapy (ACT) was deployed in 2005 as an
alternative to chloroquine and is considered the most efficacious treatment currently …
alternative to chloroquine and is considered the most efficacious treatment currently …