“Just a spoonful of sugar...”: import of sialic acid across bacterial cell membranes
Eukaryotic cell surfaces are decorated with a complex array of glycoconjugates that are
usually capped with sialic acids, a large family of over 50 structurally distinct nine-carbon …
usually capped with sialic acids, a large family of over 50 structurally distinct nine-carbon …
The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with
negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived …
negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived …
Structure and inhibition of N‐acetylneuraminate lyase from methicillin‐resistant Staphylococcus aureus
N‐Acetylneuraminate lyase is the first committed enzyme in the degradation of sialic acid by
bacterial pathogens. In this study, we analyzed the kinetic parameters of N …
bacterial pathogens. In this study, we analyzed the kinetic parameters of N …
The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus
D Coombes, JS Davies, MC Newton-Vesty… - Journal of Biological …, 2020 - ASBMB
In environments where glucose is limited, some pathogenic bacteria metabolize host-
derived sialic acid as a nutrient source. N-Acetylmannosamine kinase (NanK) is the second …
derived sialic acid as a nutrient source. N-Acetylmannosamine kinase (NanK) is the second …
Characterization of a novel N-acetylneuraminic acid lyase favoring industrial N-acetylneuraminic acid synthesis process
N-Acetylneuraminic acid lyase (NAL, EC number 4.1. 3.3) is a Class I aldolase that catalyzes
the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from pyruvate and N …
the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from pyruvate and N …
Recombinant snail sialic acid aldolase is promiscuous towards aliphatic aldehydes
ZX Hu, C Cheng, YQ Li, XH Qi, T Wang, L Liu… - …, 2022 - Wiley Online Library
Aldolases are enzymes that reversibly catalyze the cleavage of carbon‐carbon bonds. Here
we describe a recombinant sialic acid aldolase originating from the freshwater snail …
we describe a recombinant sialic acid aldolase originating from the freshwater snail …
[PDF][PDF] Crystal structure of N-acetylmannosamine kinase from Fusobacterium nucleatum
Sialic acids comprise a varied group of nine-carbon amino sugars that are widely distributed
among mammals and higher metazoans. Some human commensals and bacterial …
among mammals and higher metazoans. Some human commensals and bacterial …
Features and structure of a cold active N-acetylneuraminate lyase
MK Gurung, B Altermark, R Helland, AO Smalås… - Plos one, 2019 - journals.plos.org
N-acetylneuraminate lyases (NALs) are enzymes that catalyze the reversible cleavage and
synthesis of sialic acids. They are therefore commonly used for the production of these high …
synthesis of sialic acids. They are therefore commonly used for the production of these high …
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine-6-phosphate 2-epimerase from methicillin-resistant …
Sialic acids are one of the most important carbohydrate classes in biology. Some bacterial
pathogens can scavenge sialic acids from their surrounding environment and degrade them …
pathogens can scavenge sialic acids from their surrounding environment and degrade them …
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine kinase from methicillin-resistant Staphylococcus …
N-Acetylmannosamine kinase (EC 2.7. 1.60) is involved in the catabolism of sialic acid for
many bacterial pathogens implicated in human disease such as Escherichia coli …
many bacterial pathogens implicated in human disease such as Escherichia coli …