NAD metabolism: Role in senescence regulation and aging
The geroscience hypothesis proposes that addressing the biology of aging could directly
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …
Rebalancing the unbalanced aged immune system–A special focus on zinc
BR Baarz, L Rink - Ageing research reviews, 2022 - Elsevier
Nowadays, aging is understood as a dynamic and multifaceted dysregulation process that
spares almost no human organ or cell. The immune system being among the most affected …
spares almost no human organ or cell. The immune system being among the most affected …
Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue
Human telomere biology disorders (TBD)/short telomere syndromes (STS) are
heterogeneous disorders caused by inherited loss-of-function mutations in telomere …
heterogeneous disorders caused by inherited loss-of-function mutations in telomere …
DNA methylation variations and epigenetic aging in telomere biology disorders
O Carlund, A Norberg, P Osterman, M Landfors… - Scientific Reports, 2023 - nature.com
Abstract Telomere Biology Disorders (TBDs) are characterized by mutations in telomere-
related genes leading to short telomeres and premature aging but with no strict correlation …
related genes leading to short telomeres and premature aging but with no strict correlation …
Optimization of biotransformation processes of Camarosporium laburnicola to improve production yields of potent telomerase activators
Background Telomerase activators are promising agents for the healthy aging process and
the treatment/prevention of short telomere-related and age-related diseases. The discovery …
the treatment/prevention of short telomere-related and age-related diseases. The discovery …
Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length
Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity.
Spaceflight elongates human telomeres in peripheral blood, which shorten upon return to …
Spaceflight elongates human telomeres in peripheral blood, which shorten upon return to …
Telomere dysfunction in idiopathic pulmonary fibrosis
K Zhang, L Xu, YS Cong - Frontiers in Medicine, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis is an age-dependent progressive and fatal lung disease of
unknown etiology, which is characterized by the excessive accumulation of extracellular …
unknown etiology, which is characterized by the excessive accumulation of extracellular …
TELO-SCOPE study: a randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis
JA Mackintosh, M Pietsch, V Lutzky… - BMJ open …, 2021 - bmjopenrespres.bmj.com
Introduction Recent discoveries have identified shortened telomeres and related mutations
in people with pulmonary fibrosis (PF). There is evidence to suggest that androgens …
in people with pulmonary fibrosis (PF). There is evidence to suggest that androgens …
Age‐related telomere attrition in the human putamen
Age is a major risk factor for neurodegenerative diseases. Shortening of leucocyte telomeres
with advancing age, arguably a measure of “biological” age, is a known phenomenon and …
with advancing age, arguably a measure of “biological” age, is a known phenomenon and …
Telomere biology: from disorders to hematological diseases
Variations in the length of telomeres and pathogenic variants involved in telomere length
maintenance have been correlated with several human diseases. Recent breakthroughs in …
maintenance have been correlated with several human diseases. Recent breakthroughs in …