Interventions to attenuate vascular calcification progression in chronic kidney disease: a systematic review of clinical trials

C Xu, ER Smith, MK Tiong, I Ruderman… - Journal of the …, 2022 - journals.lww.com
Interventions To Attenuate Vascular Calcification Progressio... : Journal of the American
Society of Nephrology Interventions To Attenuate Vascular Calcification Progression in Chronic …

Mitochondrial dysfunction: cause or consequence of vascular calcification?

K Phadwal, C Vrahnas, IG Ganley… - Frontiers in cell and …, 2021 - frontiersin.org
Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells,
which can generate and sequester toxic reactive oxygen species (ROS) in response to …

[HTML][HTML] A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

X Luo, X Weng, X Bao, X Bai, Y Lv, S Zhang, Y Chen… - Redox Biology, 2022 - Elsevier
Natural antioxidants represented by quercetin have been documented to be effective
against atherosclerosis. However, the related mechanisms remain largely unclear. In this …

Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

M Kavousi, MM Bos, HJ Barnes, CL Lino Cardenas… - Nature …, 2023 - nature.com
Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future
symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may …

Carotid artery plaque calcifications: lessons from histopathology to diagnostic imaging

L Saba, V Nardi, R Cau, A Gupta, H Kamel, JS Suri… - Stroke, 2022 - Am Heart Assoc
The role of calcium in atherosclerosis is controversial and the relationship between vascular
calcification and plaque vulnerability is not fully understood. Although calcifications are …

[HTML][HTML] Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

JV Mosquera, G Auguste, D Wong, AW Turner… - Cell Reports, 2023 - cell.com
Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the
arterial wall. CAD progression involves complex interactions and phenotypic plasticity …

Two-faced Janus: the dual role of macrophages in atherosclerotic calcification

OJ Waring, NT Skenteris, EAL Biessen… - Cardiovascular …, 2022 - academic.oup.com
Calcification is an independent predictor of atherosclerosis-related cardiovascular events.
Microcalcification is linked to inflamed, unstable lesions, in comparison to the fibrotic stable …

NLRP3 inflammasome in atherosclerosis: putting out the fire of inflammation

BZ Shao, HY Xu, YC Zhao, XR Zheng, F Wang… - Inflammation, 2023 - Springer
Atherosclerosis (AS) is a chronic inflammatory disease with thickening or hardening of the
arteries, which led to the built-up of plaques in the inner lining of an artery. Among all the …

[HTML][HTML] CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque

A Sakamoto, R Kawakami, M Mori, L Guo, KH Paek… - JCI insight, 2023 - ncbi.nlm.nih.gov
Vascular calcification (VC) is concomitant with atherosclerosis, yet it remains uncertain why
rupture-prone high-risk plaques do not typically show extensive calcification. Intraplaque …

Coronary artery calcification: current concepts and clinical implications

C Onnis, R Virmani, K Kawai, V Nardi, A Lerman… - Circulation, 2024 - Am Heart Assoc
Coronary artery calcification (CAC) accompanies the development of advanced
atherosclerosis. Its role in atherosclerosis holds great interest because the presence and …