Genomic and neuroimaging approaches to bipolar disorder
MO Kohshour, S Papiol, CRK Ching, TG Schulze - BJPsych open, 2022 - cambridge.org
Background To date, besides genome-wide association studies, a variety of other genetic
analyses (eg polygenic risk scores, whole-exome sequencing and whole-genome …
analyses (eg polygenic risk scores, whole-exome sequencing and whole-genome …
Update on genetics of attention deficit/hyperactivity disorder: current status 2023
We provide a concise overview on how genetic analysis, with a focus on GWAS and PRS,
can help explain different behavioural phenotypes in ADHD and how they can be used for …
can help explain different behavioural phenotypes in ADHD and how they can be used for …
Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth
There is a gap in knowledge regarding the polygenic underpinnings of brain anomalies
observed in youth bipolar disorder (BD). This study examined the association of a polygenic …
observed in youth bipolar disorder (BD). This study examined the association of a polygenic …
Role of polygenic risk score in the familial transmission of bipolar disorder in youth
Importance Establishing genetic contributions to the transmission of bipolar disorder (BD)
from parents to offspring may inform the risk of developing this disorder and further serve to …
from parents to offspring may inform the risk of developing this disorder and further serve to …
Clinical and genetic differences between bipolar disorder type 1 and 2 in multiplex families
J Guzman-Parra, F Streit, AJ Forstner… - Translational …, 2021 - nature.com
The two major subtypes of bipolar disorder (BD), BD-I and BD-II, are distinguished based on
the presence of manic or hypomanic episodes. Historically, BD-II was perceived as a less …
the presence of manic or hypomanic episodes. Historically, BD-II was perceived as a less …
Common risk variants for epilepsy are enriched in families previously targeted for rare monogenic variant discovery
Background The epilepsies are highly heritable conditions that commonly follow complex
inheritance. While monogenic causes have been identified in rare familial epilepsies, most …
inheritance. While monogenic causes have been identified in rare familial epilepsies, most …
Association of polygenic risk for bipolar disorder with resting-state network functional connectivity in youth with and without bipolar disorder
Little is known regarding the polygenic underpinnings of anomalous resting-state functional
connectivity (rsFC) in youth bipolar disorder (BD). The current study examined the …
connectivity (rsFC) in youth bipolar disorder (BD). The current study examined the …
Psychiatric Polygenic Risk Scores Across Youth With Bipolar Disorder, Youth at High Risk for Bipolar Disorder, and Controls
Objective There is a pronounced gap in knowledge regarding polygenic underpinnings of
youth bipolar disorder (BD). This study aimed to compare polygenic risk scores (PRSs) in …
youth bipolar disorder (BD). This study aimed to compare polygenic risk scores (PRSs) in …
Polygenic scores for psychiatric disease: from research tool to clinical application
TFM Andlauer, MM Nöthen - Medizinische Genetik, 2020 - degruyter.com
Propensity to psychiatric disease involves the contribution of multiple genetic variants with
small individual effects (ie, polygenicity). This contribution can be summarized using …
small individual effects (ie, polygenicity). This contribution can be summarized using …
Factor analysis of lifetime psychopathology and its brain morphometric and genetic correlates in a transdiagnostic sample
There is a lack of knowledge regarding the relationship between proneness to dimensional
psychopathological syndromes and the underlying pathogenesis across major psychiatric …
psychopathological syndromes and the underlying pathogenesis across major psychiatric …