Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

Increased extracellular matrix (ECM) stiffness has been implicated in esophageal
adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the …

Cardiovascular diseases remain the leading cause of death worldwide; hence there is an
increasing focus on developing physiologically relevant in vitro cardiovascular tissue …

Traction force microscopy (TFM) has emerged as a versatile technique for the measurement
of single-cell-generated forces. TFM has gained wide use among mechanobiology …

The assembly of the embryo's primary axis is a fundamental landmark for the establishment
of the vertebrate body plan. Although the morphogenetic movements directing cell …

Abstract Phosphatidylinositol-5-phosphate (PtdIns5P)− 4-kinases (PIP4Ks) are stress-
regulated phosphoinositide kinases able to phosphorylate PtdIns5P to PtdIns (4, 5) P2. In …

During morphogenesis, molecular mechanisms that orchestrate biomechanical dynamics
across cells remain unclear. Here, we show a role of guidance receptor Plexin-B2 in …

The senescence of alveolar type II (AT2) cells impedes self-repair of the lung epithelium and
contributes to lung injury in the setting of idiopathic pulmonary fibrosis (IPF). Yes-associated …

Neuroepithelial (NE) organoids with dorsal–ventral patterning provide a useful three‐
dimensional (3D) in vitro model to interrogate neural tube formation during early …