A comprehensive review of circRNA: from purification and identification to disease marker potential

S Xu, LY Zhou, M Ponnusamy, LX Zhang, YH Dong… - PeerJ, 2018 - peerj.com
Circular RNA (circRNA) is an endogenous noncoding RNA with a covalently closed cyclic
structure. Based on their components, circRNAs are divided into exonic circRNAs, intronic …

The emerging role of circRNAs and their clinical significance in human cancers

L Qian, S Yu, Z Chen, Z Meng, S Huang… - Biochimica et Biophysica …, 2018 - Elsevier
Circular RNA (circRNA), a recently discovered subclass of non-coding RNAs (ncRNAs),
forms a covalently closed loop with neither a 5′ cap structure nor a 3′ polyadenylated tail …

The fission yeast cell integrity pathway: a functional hub for cell survival upon stress and beyond

J Cansado, T Soto, A Franco, J Vicente-Soler… - Journal of Fungi, 2021 - mdpi.com
The survival of eukaryotic organisms during environmental changes is largely dependent on
the adaptive responses elicited by signal transduction cascades, including those regulated …

Sequestration of the PKC ortholog Pck2 in stress granules as a feedback mechanism of MAPK signaling in fission yeast

Y Kanda, R Satoh, T Takasaki… - Journal of Cell …, 2021 - journals.biologists.com
Protein kinase C (PKC) signaling is a highly conserved signaling module that plays a central
role in a myriad of physiological processes, ranging from cell proliferation to cell death, via …

Identification of ACA‐28, a 1′‐acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human …

R Satoh, K Hagihara, K Matsuura, Y Manse… - Genes to …, 2017 - Wiley Online Library
The extracellular signal‐regulated kinase (ERK) signaling pathway is essential for cell
proliferation and is frequently deregulated in human tumors such as melanoma. Melanoma …

[HTML][HTML] Atg1, a key regulator of autophagy, functions to promote MAPK activation and cell death upon calcium overload in fission yeast

T Takasaki, R Utsumi, E Shimada, A Bamba… - Microbial Cell, 2023 - ncbi.nlm.nih.gov
Autophagy promotes or inhibits cell death depending on the environment and cell type. Our
previous findings suggested that Atg1 is genetically involved in the regulation of Pmk1 …

The multiple functions of Rho GTPases in fission yeasts

J Vicente-Soler, T Soto, A Franco, J Cansado… - Cells, 2021 - mdpi.com
The Rho family of GTPases represents highly conserved molecular switches involved in a
plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has …

Phase separation orchestrates cancer signaling: Stress granules as a promising target for cancer therapy

R Sugiura, R Satoh, N Tomimoto, T Takasaki - Phase Separation in Living …, 2023 - Springer
Liquid–liquid phase separation (LLPS) has recently emerged as a new fundamental
mechanism for the eukaryotic cellular organization via the formation of membrane-less …

Fungal homologues of human Rac1 as emerging players in signal transduction and morphogenesis

J Hühn, M Musielak, HP Schmitz, JJ Heinisch - International Microbiology, 2020 - Springer
A wealth of data is accumulating on the physiological functions of human Rac1, a member of
the Rho GTPase family of molecular switches and substrate of botulinum toxin, which was …

[HTML][HTML] A central role for TOR signalling in a yeast model for juvenile CLN3 disease

ME Bond, R Brown, C Rallis, J Bähler, SE Mole - Microbial Cell, 2015 - ncbi.nlm.nih.gov
Yeasts provide an excellent genetically tractable eukaryotic system for investigating the
function of genes in their biological context, and are especially relevant for those conserved …