Shock is characterized by cellular and tissue hypoxia, caused by increased oxygen demand,
insufficient oxygen delivery, impaired oxygen utilization, or a combination of these factors. 1 …

Hydroxocobalamin inhibits nitric oxide-mediated vasodilation, and has been used in settings
of refractory shock. However, its effectiveness and role in treating hypotension remain …

The management of a large burn can prove to be extremely challenging. When this is
compounded by the presence of smoke inhalation, the care gets even more complex with a …

Objectives Hydroxocobalamin inhibits nitric oxide pathways contributing to vasoplegic shock
in patients undergoing cardiopulmonary bypass (CPB). The objective of this study was to …

High‐dose vitamin B12 is a potential treatment for patients with vasodilatory shock that is
refractory to other therapies. Vasodilatory shock is characterized by low blood pressure and …

Introduction Septic and vasoplegic shock are common types of vasodilatory shock (VS) with
high mortality. After fluid resuscitation and the use of catecholamine-mediated vasopressors …

All patients with septic shock should be given the fundamental pillars of sepsis management
(source control, antibiotic stewardship, initial hemodynamic resuscitation, and multi-organ …

维生素是人体必需的微量营养素, 生理作用相当广泛, 在许多与脓毒症相关的生物学途径中起着
关键作用, 包括抗氧化和抗炎作用, 蛋白质和激素合成, 能量产生和基因转录的调节等. 此外 …

Objectives Refractory distributive shock (vasoplegia) has been treated with intravenous (IV)
hydroxocobalamin (B12), but its use is poorly characterized. The objective of this study was …

We eagerly read the results by Patel et al 1 in this issue of CHEST regarding the
vasopressor-sparing effects of a single high dose (5 g IV) of vitamin B12 (hydroxocobalamin …