Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues

DB Hier, T Obafemi-Ajayi, MS Thimgan, GR Olbricht… - Biomarker …, 2021 - Springer
Background The use of blood biomarkers after mild traumatic brain injury (mTBI) has been
widely studied. We have identified eight unresolved issues related to the use of five …

Extracellular vesicle proteins and microRNAs as biomarkers for traumatic brain injury

VA Guedes, C Devoto, J Leete, D Sass, JD Acott… - Frontiers in …, 2020 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous condition, associated with diverse etiologies,
clinical presentations and degrees of severity, and may result in chronic neurobehavioral …

Exosomal neurofilament light: A prognostic biomarker for remote symptoms after mild traumatic brain injury?

VA Guedes, K Kenney, P Shahim, BX Qu, C Lai… - Neurology, 2020 - AAN Enterprises
Objective To measure exosomal and plasma levels of candidate blood biomarkers in
veterans with history of mild traumatic brain injury (mTBI) and test their relationship with …

Plasma biomarker concentrations associated with return to sport following sport-related concussion in collegiate athletes—a concussion assessment, research, and …

CL Pattinson, TB Meier, VA Guedes, C Lai… - JAMA network …, 2020 - jamanetwork.com
Importance Identifying plasma biomarkers associated with the amount of time an athlete may
need before they return to sport (RTS) following a sport-related concussion (SRC) is …

Serum tau, neurofilament light chain, glial fibrillary acidic protein, and ubiquitin carboxyl-terminal hydrolase L1 are associated with the chronic deterioration of …

RT Lange, S Lippa, TA Brickell, J Gill… - Journal of …, 2023 - liebertpub.com
The purpose of this study was to examine the association of serum tau, neurofilament light
chain (NFL), glial fibrillary acidic protein (GFAP), and ubiquitin carboxy-terminal hydrolase …

Prognostic models for global functional outcome and post-concussion symptoms following mild traumatic brain Injury: a collaborative European NeuroTrauma …

A Mikolić, EW Steyerberg, S Polinder… - Journal of …, 2023 - liebertpub.com
After mild traumatic brain injury (mTBI), a substantial proportion of individuals do not fully
recover on the Glasgow Outcome Scale Extended (GOSE) or experience persistent post …

[HTML][HTML] Neurochemical markers of traumatic brain injury: relevance to acute diagnostics, disease monitoring, and neuropsychiatric outcome prediction

P Shahim, H Zetterberg - Biological psychiatry, 2022 - Elsevier
Considerable advancements have been made in the quantification of biofluid-based
biomarkers for traumatic brain injury (TBI), which provide a clinically accessible window to …

A kinetic model for blood biomarker levels after mild traumatic brain injury

S Azizi, DB Hier, B Allen, T Obafemi-Ajayi… - Frontiers in …, 2021 - frontiersin.org
Traumatic brain injury (TBI) imposes a significant economic and social burden. The
diagnosis and prognosis of mild TBI, also called concussion, is challenging. Concussions …

The evolving role of extracellular vesicles (exosomes) as biomarkers in traumatic brain injury: Clinical perspectives and therapeutic implications

NA Khan, M Asim, A El-Menyar, KH Biswas… - Frontiers in Aging …, 2022 - frontiersin.org
Developing effective disease-modifying therapies for neurodegenerative diseases (NDs)
requires reliable diagnostic, disease activity, and progression indicators. While desirable …

Dietary supplementation with branched chain amino acids to improve sleep in veterans with traumatic brain injury: a randomized double-blind placebo-controlled pilot …

JE Elliott, AT Keil, S Mithani, JM Gill… - Frontiers in systems …, 2022 - frontiersin.org
Study Objectives Traumatic brain injury (TBI) is associated with chronic sleep disturbances
and cognitive impairment. Our prior preclinical work demonstrated dietary supplementation …