The pathomechanism, antioxidant biomarkers, and treatment of oxidative stress-related eye diseases

YJ Hsueh, YN Chen, YT Tsao, CM Cheng… - International Journal of …, 2022 - mdpi.com
Oxidative stress is an important pathomechanism found in numerous ocular degenerative
diseases. To provide a better understanding of the mechanism and treatment of …

Corticosteroids in ophthalmology: Drug delivery innovations, pharmacology, clinical applications, and future perspectives

SA Gaballa, UB Kompella, O Elgarhy… - Drug Delivery and …, 2021 - Springer
Corticosteroids remain the mainstay of the treatment for various ocular conditions affecting
the ocular surface, anterior and posterior segments of the eye due to their anti-inflammatory …

Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants

H Abdelkader, Z Fathalla, A Seyfoddin… - Advanced drug delivery …, 2021 - Elsevier
Non-oral long-acting drug delivery systems (LADDS) encompass a range of technologies for
precisely delivering drug molecules into target tissues either through the systemic circulation …

Role of oxidative stress in ocular diseases: a balancing act

DY Shu, S Chaudhary, KS Cho, A Lennikov, WP Miller… - Metabolites, 2023 - mdpi.com
Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

Biology of inherited cataracts and opportunities for treatment

A Shiels, JF Hejtmancik - Annual review of vision science, 2019 - annualreviews.org
Cataract, the clinical correlate of opacity or light scattering in the eye lens, is usually caused
by the presence of high-molecular-weight (HMW) protein aggregates or disruption of the …

An insight on ophthalmic drug delivery systems: focus on polymeric biomaterials-based carriers

M Shafiq, M Rafique, Y Cui, L Pan, CW Do… - Journal of Controlled …, 2023 - Elsevier
Presently, different types of eye diseases, such as glaucoma, myopia, infection, and dry eyes
are treated with topical eye drops. However, due to ocular surface barriers, eye drops …

Posterior segment ophthalmic drug delivery: Role of muco-adhesion with a special focus on chitosan

AM Burhan, B Klahan, W Cummins, V Andrés-Guerrero… - Pharmaceutics, 2021 - mdpi.com
Posterior segment eye diseases (PSEDs) including age macular degeneration (AMD) and
diabetic retinopathy (DR) are amongst the major causes of irreversible blindness worldwide …

Role of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4) in tumor cells and the tumor microenvironment

T Liu, S Han, Y Yao, G Zhang - Cancer Management and Research, 2023 - Taylor & Francis
In recent years, the abnormal glucose metabolism of tumor cells has attracted increasing
attention. Abnormal glucose metabolism is closely related to the occurrence and …

Benzydamine—An affordable over-the-counter drug with psychoactive properties—From chemical structure to possible pharmacological properties

BE Ősz, G Jîtcă, A Sălcudean, CM Rusz, CE Vari - Pharmaceuticals, 2023 - mdpi.com
Benzydamine is a non-steroidal anti-inflammatory drug with distinct pharmacological
properties from other compounds in the same therapeutic class. The differences are …

Age‐dependent changes in glutathione metabolism pathways in the lens: New insights into therapeutic strategies to prevent cataract formation—A review

JC Lim, AC Grey, A Zahraei… - Clinical & Experimental …, 2020 - Wiley Online Library
Ocular tissues possess a robust antioxidant defence system to minimize oxidative stress and
preserve tissue structure and function. Glutathione (GSH) is a powerful antioxidant and in …