Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for
millisecond resolution control of neural activity. By targeting opsin expression to specific cell …

Many studies have shown that the excitation and inhibition received by cortical neurons
remain roughly balanced across many conditions. A key question for understanding the …

A fundamental impediment to understanding the brain is the availability of inexpensive and
robust methods for targeting and manipulating specific neuronal populations. The need to …

Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on
animal models more closely related to humans, such as non-human primates (NHPs), has …

Optogenetics is among the most widely employed techniques to manipulate neuronal
activity. However, a major drawback is the need for invasive implantation of optical fibers. To …

Attention is critical to perception, serving to select behaviorally relevant information for
privileged processing. To understand the neural mechanisms of attention, we must discern …

Digitized neuroanatomical atlases that can be overlaid onto functional data are crucial for
localizing brain structures and analyzing functional networks identified by neuroimaging …

Successful application of two-photon imaging with genetic tools in awake macaque
monkeys will enable fundamental advances in our understanding of higher cognitive …

Optogenetic methods have been highly effective for suppressing neural activity and
modulating behavior in rodents, but effects have been much smaller in primates, which have …

While optogenetics offers great potential for linking brain function and behavior in
nonhuman primates, taking full advantage of that potential will require stable access for …