Polyunsaturated fatty acids and their potential therapeutic role in cardiovascular system disorders—a review

E Sokoła-Wysoczańska, T Wysoczański, J Wagner… - Nutrients, 2018 - mdpi.com
Cardiovascular diseases are described as the leading cause of morbidity and mortality in
modern societies. Therefore, the importance of cardiovascular diseases prevention is widely …

Exosomes/miRNAs as mediating cell-based therapy of stroke

H Xin, Y Li, M Chopp - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Cell-based therapy, eg, multipotent mesenchymal stromal cell (MSC) treatment, shows
promise for the treatment of various diseases. The strong paracrine capacity of these cells …

Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression

TR Doeppner, J Herz, A Görgens… - Stem cells …, 2015 - academic.oup.com
Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent
evidence has suggested that stem and progenitor cells alike promote postischemic …

Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and …

J Gregorius, C Wang, O Stambouli, T Hussner… - Basic research in …, 2021 - Springer
Obtained from the right cell-type, mesenchymal stromal cell (MSC)-derived small
extracellular vesicles (sEVs) promote stroke recovery. Within this process, microvascular …

Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy

T Li, M Xia, Y Gao, Y Chen, Y Xu - Expert opinion on biological …, 2015 - Taylor & Francis
Introduction: Human umbilical cord mesenchymal stem cells (HUC-MSCs) are one of the
typical adult stem cells; they have superiorities including low immunogenicity, non-invasive …

Neuroprotection for ischaemic stroke: current status and challenges

A Moretti, F Ferrari, RF Villa - Pharmacology & therapeutics, 2015 - Elsevier
Stroke is the third cause of death worldwide and the main cause of chronic, severe adult
disability. We focus on acute ischaemic stroke, which accounts for approximately 80% of all …

[图书][B] Broken movement: the neurobiology of motor recovery after stroke

JW Krakauer, ST Carmichael - 2022 - books.google.com
An account of the neurobiology of motor recovery in the arm and hand after stroke by two
experts in the field. Stroke is a leading cause of disability in adults and recovery is often …

Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)

A Dávalos, J Alvarez-Sabín, J Castillo, E Díez-Tejedor… - The Lancet, 2012 - thelancet.com
Background Citicoline is approved in some countries for the treatment of acute ischaemic
stroke. The drug has shown some evidence of efficacy in a pooled analysis. We sought to …

Multicellular crosstalk between exosomes and the neurovascular unit after cerebral ischemia. Therapeutic implications

AM Zagrean, DM Hermann, I Opris, L Zagrean… - Frontiers in …, 2018 - frontiersin.org
Restorative strategies after stroke are focused on the remodeling of cerebral endothelial
cells and brain parenchymal cells. The latter, ie, neurons, neural precursor cells and glial …

Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials

J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …