Heart failure is a major cause of death and disability. Impairments in blood circulation that
accompany heart failure can be traced, in part, to alterations in the activity of the …

The calcium pump (aka Ca 2+-ATPase or SERCA) is a membrane transport protein
ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Simmerman, Heather KB, and Larry R. Jones. Phospholamban: Protein Structure,
Mechanism of Action, and Role in Cardiac Function. Physiol. Rev. 78: 921–947, 1998.—A …

Intracellular Ca2+-transport ATPases exert a pivotal role in the endoplasmic reticulum and in
the compartments of the cellular secretory pathway by maintaining a sufficiently high …

This review describes:(i) perturbations of the membrane lipids that are induced by integral
membrane proteins, and reciprocally,(ii) the effects that the lipids may have on the function …

Cardiac sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) plays a central role in
myocardial contractility. SERCA2a actively transports Ca2+ into the SR and regulates …

It is shown that molecular structure and dynamics of a uniformly labeled membrane protein
can be studied under magic-angle-spinning conditions. For this purpose, dipolar recoupling …

The control of intracellular calcium is central to regulation of cardiac contractility. A defect in
SR Ca2+ transport and SR Ca2+ ATPase pump activity and expression level has been …

This paper reviews various enhanced conformational sampling methods and explicit/implicit
solvent/membrane models, as well as their recent applications to the exploration of the …