Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

The Martini model, a coarse-grained force field for biomolecular simulations, has found a
broad range of applications since its release a decade ago. Based on a building block …

The Martini coarse-grained force field has been successfully used for simulating a wide
range of (bio) molecular systems. Recent progress in our ability to test the model against …

How proteins specifically localize to the phospholipid monolayer surface of lipid droplets
(LDs) is being unraveled. We review here the major known pathways of protein targeting to …

Human cornea is covered by an aqueous tear film, and the outermost layer of the tear film is
coated by lipids. This so-called tear film lipid layer (TFLL) reduces surface tension of the tear …

Intracellular lipid droplets (LDs) are the main cellular site of metabolic energy storage. Their
structure is unique inside the cell, with a core of esterified fatty acids and sterols, mainly …

Experimental characterization of membrane proteins often requires solubilization. A recent
approach is to use styrene-maleic acid (SMA) copolymers to isolate membrane proteins in …

Lipid droplets (LDs) are intracellular organelles whose primary function is energy storage.
Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs have a unique structure …

Diacylglycerols (DAGs) are bioactive lipids that are ubiquitously present at low
concentrations in cellular membranes. Upon the activation of lipid remodeling enzymes such …

Lipids are a diverse group of metabolites that have many key biological functions, acting as
structural components of cell membranes, energy storage sources and intermediates in …