Importance Observational (nonexperimental) studies that aim to emulate a randomized trial
(ie, the target trial) are increasingly informing medical and policy decision-making, but it is …

The process of aging population will inevitably increase age-related comorbidities including
chronic kidney disease (CKD). In light of this demographic transition, the lack of an age …

High levels of uric acid (UA) in humans can cause a range of diseases, and traditional
assays that rely on uric acid enzymes to break down uric acid are limited by the inherent …

The global prevalence and incidence of chronic kidney disease (CKD) continue to increase.
Whether hyperuricemia is an independent risk factor for renal progression and whether …

Ethnopharmacological relevance Simiao San (SmS), a famous traditional Chinese formula,
is clinically used to treat patients with hyperuricemia (HUA). However, its mechanism of …

Introduction Researchers have investigated the causal effect between serum uric acid (SUA)
concentrations and kidney function for decades, but studies produced inconsistent results …

Serum uric acid levels are altered by kidney disorders because the kidneys play a dominant
role in uric acid excretion. Here, major kidney disorders which accompany hyperuricemia or …

Background Chronic microinflammation contributes to the progression of chronic kidney
disease (CKD). Aspirin (ASA) has been used to treat inflammation for centuries. The effects …

Introduction/objectives Persistent hyperuricemia is a key factor in gout; however, only 13.5%
of hyperuricemic individuals manifest the disease. The gut microbiota could be one of the …

The impact of elevated serum uric acid levels ie, hyperuricemia, on native and transplant
chronic kidney disease progression has been debated. This literature review presents an …