The biology of telomeres and telomerase has been the subject of intensive investigative
effort since it became evident that they play a significant role in two important biological …

Telomeres are multi-component DNA–protein complexes protecting linear chromosome
termini against degradation and fusion. Telomeres and their components are involved in …

Telomeric DNA consists of short, tandemly repeated sequences at the ends of
chromosomes. Telomeric DNA in the ciliate Paramecium tetraurelia is synthesized by an …

Objective. Telomerase is capable of restoring telomeric sequence lost during replication. No
or low levels of telomerase activity are present in normal somatic cells, whereas up to 85 …

В обзорной статье рассматривается структура теломер―концевых участков линейной
хромосомr ной ДНК. Приводятся особенности нуклеотидной организации теломерной …

Обзор посвящен рассмотрению структуры теломер–концевых участков линейной
хромосомной ДНК в контексте проблемы старения. Приводятся особенности …

Previous studies from our laboratory have demonstrated that, in adult rats following forelimb
amputation on the day of birth, approximately one-third of multi-unit recording sites in the …

DNA is constantly challenged by damage originating from environmental agents and
endogenous mutagens (Wood et al., 2001). Cells must efficiently repair damaged DNA to …

The process of homologous genetic recombination is essential for increasing genetic
diversity, maintaining chromosome and telomere structure, and repairing DNA damage. A …

Telomerase is a ribonucleoprotein enzyme responsible for the synthesis of telomeric DNA at
chromosome ends. The RNA moiety functions as a template for the synthesis of the G-rich …