Trafficking and proteolytic processing of amyloid precursor protein and secretases in Alzheimer's disease development: an up-to-date review
M Yuksel, O Tacal - European journal of pharmacology, 2019 - Elsevier
Abstract Alzheimer's disease (AD), which is predicted to affect 1 in 85 persons worldwide by
2050, results in progressive loss of neuronal functions, leading to impairments in memory …
2050, results in progressive loss of neuronal functions, leading to impairments in memory …
Challenges in LC–MS-based metabolomics for Alzheimer's disease early detection: Targeted approaches versus untargeted approaches
P Reveglia, C Paolillo, G Ferretti, A De Carlo… - Metabolomics, 2021 - Springer
Background Alzheimer's disease (AD) is one of the most common causes of dementia in old
people. Neuronal deficits such as loss of memory, language and problem-solving are …
people. Neuronal deficits such as loss of memory, language and problem-solving are …
Three dimensional human neuro-spheroid model of Alzheimer's disease based on differentiated induced pluripotent stem cells
HK Lee, C Velazquez Sanchez, M Chen, PJ Morin… - PloS one, 2016 - journals.plos.org
The testing of candidate drugs to slow progression of Alzheimer's disease (AD) requires
clinical trials that are lengthy and expensive. Efforts to model the biochemical milieu of the …
clinical trials that are lengthy and expensive. Efforts to model the biochemical milieu of the …
Endocytosis and Alzheimer's disease
Ł Zadka, M Sochocka, N Hachiya… - Geroscience, 2024 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most
common cause of dementia. The pathogenesis of AD still remains unclear, including two …
common cause of dementia. The pathogenesis of AD still remains unclear, including two …
Fyn tyrosine kinase elicits amyloid precursor protein Tyr682 phosphorylation in neurons from Alzheimer's disease patients
F Iannuzzi, R Sirabella, N Canu, TJ Maier… - Cells, 2020 - mdpi.com
Alzheimer's disease (AD) is an incurable neurodegenerative disorder with a few early
detection strategies. We previously proposed the amyloid precursor protein (APP) tyrosine …
detection strategies. We previously proposed the amyloid precursor protein (APP) tyrosine …
[HTML][HTML] The paradigm of amyloid precursor protein in amyotrophic lateral sclerosis: The potential role of the 682YENPTY687 motif
C Matrone - Computational and Structural Biotechnology Journal, 2023 - Elsevier
Neurodegenerative diseases are characterized by the progressive decline of neuronal
function in several brain areas, and are always associated with cognitive, psychiatric, or …
function in several brain areas, and are always associated with cognitive, psychiatric, or …
The MUC6/AP2A2 Locus and Its Relevance to Alzheimer's Disease: A Review
We recently reported evidence of Alzheimer's disease (AD)-linked genetic variation within
the mucin 6 (MUC6) gene on chromosome 11p, nearby the adaptor-related protein complex …
the mucin 6 (MUC6) gene on chromosome 11p, nearby the adaptor-related protein complex …
Proteins involved in endocytosis are upregulated by ageing in the normal human brain: implications for the development of Alzheimer's disease
M Alsaqati, RS Thomas, EJ Kidd - The Journals of Gerontology …, 2018 - academic.oup.com
The greatest risk factor for Alzheimer's disease (AD) is advanced age, but the reason for this
association remains unclear. Amyloid-β (Aβ) is produced from amyloid precursor protein …
association remains unclear. Amyloid-β (Aβ) is produced from amyloid precursor protein …
[PDF][PDF] RETRACTED: An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex …
ET Poulsen, F Iannuzzi, HF Rasmussen… - Frontiers in Molecular …, 2017 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by
defective amyloid precursor protein (APP) trafficking and processing in neurons leading to …
defective amyloid precursor protein (APP) trafficking and processing in neurons leading to …
Sortilin‐Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele
A Zollo, Z Allen, HF Rasmussen, F Iannuzzi… - Neural …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia in the elderly; important risk
factors are old age and inheritance of the apolipoprotein E4 (APOE4) allele. Changes in …
factors are old age and inheritance of the apolipoprotein E4 (APOE4) allele. Changes in …