Hydroxypropyl methylcellulose acetate succinate as an exceptional polymer for amorphous solid dispersion formulations: A review from bench to clinic

A Butreddy - European Journal of Pharmaceutics and …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) are a proven system for achieving a supersaturated
state of drug, in which the concentration of drug is greater than its crystalline solubility. The …

Impact of surfactants on the performance of clopidogrel-copovidone amorphous solid dispersions: increased drug loading and stabilization of nanodroplets

CE Correa Soto, Y Gao, AS Indulkar, K Ueda… - Pharmaceutical …, 2022 - Springer
Purpose Surfactants are increasingly being added to amorphous solid dispersion (ASDs)
formulations to enhance processability and release performance. The goal of the current …

Quantification of Caffeine Interactions in Choline Chloride Natural Deep Eutectic Solvents: Solubility Measurements and COSMO-RS-DARE Interpretation

T Jeliński, P Cysewski - International Journal of Molecular Sciences, 2022 - mdpi.com
Solubility of active pharmaceutical ingredients is an important aspect of drug processing and
formulation. Although caffeine was a subject of many studies aiming to quantify saturated …

Effects of lipid digestion and drug permeation/re-dissolution on absorption of orally administered ritonavir as different lipid-based formulations

Y Tanaka, H Doi, T Katano, S Kasaoka - European Journal of …, 2021 - Elsevier
The aim of this study is to clarify absorption mechanisms after oral administration of ritonavir
(RTV) from different types of lipid-based formulations (LBFs) with particular emphasis on the …

The combination of hydroxypropylmethylcellulose acetate succinate and L-lysine into ternary amorphous solid dispersions of quercetin to enhance its dissolution

Y Wang, W Qin, Q Liang, F Zhou, C Yan… - Carbohydrate Polymer …, 2021 - Elsevier
The purpose of this study was to enhance quercetin (Que) dissolution by preparing its
ternary amorphous solid dispersions. The ternary amorphous solid dispersions were …

Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations

M El Sayed, A Alhalaweh… - Molecular …, 2021 - ACS Publications
The solution behavior and membrane transport of multidrug formulations were herein
investigated in a biorelevant medium simulating fasted conditions. Amorphous multidrug …

Validation of RP-HPLC method for quantification of ketoconazole in two-stage model of biorelevant dissolution: application to supersaturation study

V Annisa, TNS Sulaiman, AK Nugroho… - Egyptian …, 2023 - journals.lww.com
Background Supersaturation may occur in weakly base drugs due to the physiological pH in
the gastrointestinal (GI) tract cause their pH depends on solubility. The biorelevant medium …

Increasing the Robustness of Biopharmaceutical Precipitation Assays–Part I: Derivative UV Spectrophotometric Method Development for in-line Measurements

A Lehmann, K Krollik, K Beran, C Hirtreiter… - Journal of …, 2022 - Elsevier
In vitro precipitation assays are often applied to support drug and formulation development.
Current methods applied to quantify the amount of dissolved drug, in particular (U) HPLC …

Synthesis and antibacterial activity of a ZnO-fibre complex

F Dai, T Lin, X Huang, M Shi, F Zhao… - South African Journal …, 2023 - journals.co.za
In this experiment, a ZnO-fibre complex was prepared using the hydrothermal methods of"
water solubility,"" coupling agent," and" high temperature and high pressure". Binding rate …

[PDF][PDF] Journal of Pharmaceutical Technology Research and Management

A Garcia-Radilla, M Ortiz-Reynoso, G Cuevas… - 2023 - jptrm.chitkara.edu.in
Background: Melt granulation (MG) is a simple operation involving a uniform mixture of
active ingredients with a melted polymeric carrier. However, this process can also enhance …