In light of the clinical evidence implicating dopamine in schizophrenia and the prominent
hypotheses put forth regarding alterations in dopaminergic transmission in this disease …

This review updates the existing knowledge suggesting a role for the D3 receptor in
schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling …

[11C]-(+)-PHNO is a D3 preferring PET radioligand which has recently opened the
possibility of imaging D3 receptors in the human brain in vivo. This imaging tool allows …

Background The serotonin hypothesis of depression proposes that diminished serotonergic
(5-HT) neurotransmission is causal in the pathophysiology of the disorder. Although the …

BACKGROUND: A pathologic response to common life stressors, in which a
hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic …

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and
abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc) …

Repeated exposure to drugs of abuse produces long‐term molecular and neurochemical
changes that may explain the core features of addiction, such as the compulsive seeking …

Distinguishing between meaningful and meaningless sensory information is fundamental to
forming accurate representations of the world. Dopamine is thought to play a central role in …

Obesity is typically associated with abnormal eating behaviors. Brain imaging studies in
humans implicate the involvement of dopamine (DA)-modulated circuits in pathologic eating …

This systematic review describes human molecular imaging studies which have investigated
alterations in extracellular DA levels during performance of behavioral tasks. Whilst …