Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

While the genomic revolution has dramatically accelerated the discovery of disease-
associated genes, the functional characterization of the corresponding proteins lags behind …

Protein–protein interactions (PPIs) are fundamental to the structure and function of protein
complexes. Resolving the physical contacts between proteins as they occur in cells is critical …

In Trypanosoma brucei, the editosome, composed of RNA-editing substrate-binding
complex (RESC) and RNA-editing catalytic complex (RECC), orchestrates guide RNA …

The 26S proteasome is the macromolecular machine responsible for ATP/ubiquitin
dependent degradation. As aberration in proteasomal degradation has been implicated in …

The conserved eight-subunit COP9 signalosome (CSN) is required for multicellular fungal
development. The CSN deneddylase cooperates with the Cand1 exchange factor to control …

Enzymes embedded into the RNA editing core complex (RECC) catalyze the U-
insertion/deletion editing cascade to generate open reading frames in trypanosomal …

It remains extraordinarily challenging to elucidate endogenous protein-protein interactions
and proximities within the cellular milieu. The dynamic nature and the large range of …

methylcrotonyl-CoA carboxylase (MCC) is a biotin-dependent mitochondrial enzyme
necessary for leucine catabolism in most organisms. While the crystal structure of …

Abstract Mortalin (mot-2) induces inactivation of the tumor suppressor p53's transcriptional
and apoptotic functions by cytoplasmic sequestration of p53 in select cancers. The mot-2 …