Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy

CF Rose, P Amodio, JS Bajaj, RK Dhiman… - Journal of …, 2020 - Elsevier
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver
disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric …

Metabolic-associated fatty liver disease (MAFLD): a multi-systemic disease beyond the liver

E Kaya, Y Yilmaz - Journal of clinical and translational …, 2021 - pmc.ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a multisystemic clinical condition that presents
with a wide spectrum of extrahepatic manifestations, such as obesity, type 2 diabetes …

Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum …

K Yin, D Wang, H Zhao, Y Wang, Y Zhang, Y Liu… - Environmental …, 2022 - Elsevier
Microplastics (MPs), which are emerging environmental pollutants, remain uncertainties in
their toxic mechanism. MPs have been linked to severe liver metabolic disorders and …

Physiological β-amyloid clearance by the liver and its therapeutic potential for Alzheimer's disease

Y Cheng, CY He, DY Tian, SH Chen, JR Ren… - Acta …, 2023 - Springer
Cerebral amyloid-β (Aβ) accumulation due to impaired Aβ clearance is a pivotal event in the
pathogenesis of Alzheimer's disease (AD). Considerable brain-derived Aβ is cleared via …

Metabolic inflammation—a role for hepatic inflammatory pathways as drivers of comorbidities in nonalcoholic fatty liver disease?

N Gehrke, JM Schattenberg - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a global and growing health concern. Emerging
evidence points toward metabolic inflammation as a key process in the fatty liver that …

Cognitive dysfunction in non-alcoholic fatty liver disease—current knowledge, mechanisms and perspectives

K Kjærgaard, ACD Mikkelsen, CW Wernberg… - Journal of Clinical …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the hepatic component of the
metabolic syndrome and now seemingly affects one-fourth of the world population. Features …

Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation

SY Cheon, J Song - Cell & Bioscience, 2022 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple
pathologies. The progression of dementia with NAFLD may be affected by various risk …

Depression and cognitive impairment—extrahepatic manifestations of NAFLD and NASH

M Colognesi, D Gabbia, S De Martin - Biomedicines, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) and its complication non-alcoholic steatohepatitis
(NASH) are important causes of liver disease worldwide. Recently, a significant association …

[HTML][HTML] Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction

A Hadjihambi, C Konstantinou, J Klohs, K Monsorno… - Journal of …, 2023 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) has been associated with
mild cerebral dysfunction and cognitive decline, although the exact pathophysiological …

Mitochondrial transfer ameliorates cognitive deficits, neuronal loss, and gliosis in Alzheimer's disease mice

K Nitzan, S Benhamron, M Valitsky… - Journal of …, 2019 - content.iospress.com
Pathogenesis of neurodegenerative diseases involves dysfunction of mitochondria, one of
the most important cell organelles in the brain, with its most prominent roles in producing …