Early brain injury after subarachnoid hemorrhage: incidence and mechanisms
DC Lauzier, K Jayaraman, JY Yuan, D Diwan… - Stroke, 2023 - Am Heart Assoc
Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant
morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in …
morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in …
Microvascular dysfunction and cognitive impairment
TM De Silva, FM Faraci - Cellular and molecular neurobiology, 2016 - Springer
The impact of vascular risk factors on cognitive function has garnered much interest in recent
years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral …
years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral …
Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow
Blood flow into the brain is dynamically regulated to satisfy the changing metabolic
requirements of neurons, but how this is accomplished has remained unclear. Here we …
requirements of neurons, but how this is accomplished has remained unclear. Here we …
Cerebral autoregulation in subarachnoid hemorrhage
D Lidington, H Wan, SS Bolz - Frontiers in neurology, 2021 - frontiersin.org
Subarachnoid hemorrhage (SAH) is a devastating stroke subtype with a high rate of
mortality and morbidity. The poor clinical outcome can be attributed to the biphasic course of …
mortality and morbidity. The poor clinical outcome can be attributed to the biphasic course of …
Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes: Role of voltage-dependent calcium channels
Arteriolar smooth muscle cells (SMCs) and capillary pericytes dynamically regulate blood
flow in the central nervous system in the face of fluctuating perfusion pressures. Pressure …
flow in the central nervous system in the face of fluctuating perfusion pressures. Pressure …
Vascular Inward Rectifier K+ Channels as External K+ Sensors in the Control of Cerebral Blood Flow
TA Longden, MT Nelson - Microcirculation, 2015 - Wiley Online Library
For decades it has been known that external K+ ions are rapid and potent vasodilators that
increase CBF. Recent studies have implicated the local release of K+ from astrocytic endfeet …
increase CBF. Recent studies have implicated the local release of K+ from astrocytic endfeet …
Ion channel networks in the control of cerebral blood flow
TA Longden, DC Hill-Eubanks… - Journal of Cerebral …, 2016 - journals.sagepub.com
One hundred and twenty five years ago, Roy and Sherrington made the seminal observation
that neuronal stimulation evokes an increase in cerebral blood flow. 1 Since this discovery …
that neuronal stimulation evokes an increase in cerebral blood flow. 1 Since this discovery …
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes
Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
Subarachnoid hemorrhage: a review of experimental studies on the microcirculation and the neurovascular unit
MK Tso, RL Macdonald - Translational stroke research, 2014 - Springer
Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated
early brain injury and the microcirculation. A number of pathophysiological changes occur in …
early brain injury and the microcirculation. A number of pathophysiological changes occur in …
Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels
The cellular events that cause ischemic neurological damage following aneurysmal
subarachnoid hemorrhage (SAH) have remained elusive. We report that subarachnoid …
subarachnoid hemorrhage (SAH) have remained elusive. We report that subarachnoid …