Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Cisplatin has long been a first-line chemotherapeutic agent in the treatment of cancer,
largely for solid tumors. During the course of the past two decades, autophagy has been …

Galectins are galactoside-binding proteins, exerting numerous functions inside and outside
the cell, particularly conferring adaptation to stress factors. For most of them, aberrant …

Receptor tyrosine kinases (RTKs) constitute a large group of cell surface proteins that
mediate communication of cells with extracellular environment. RTKs recognize external …

Galectins play relevant roles in tumor development, progression and metastasis.
Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To …

Malignant peripheral nerve sheath tumors (MPNSTs) originate from the neural crest lineage
and are associated with the neurofibromatosis type I syndrome. MPNST is an unmet clinical …

Resistance to paclitaxel poses a major obstacle in esophageal squamous cell carcinoma
(ESCC) treatment. A better understanding of the mechanisms underlying paclitaxel …

Over the past few years, tumor immunotherapy has emerged as an innovative tumor
treatment and owned incomparable advantages over other tumor therapy. With unique …

Influenza remains one of the major epidemic diseases worldwide. Acute lung injury mainly
caused by excessive pro-inflammatory host immune responses leads to high mortality rates …

Purpose Galectin-1 and-3 are β-galactoside binding lectins with varying effects on
angiogenesis and apoptosis. Since in retinal pigment epithelial cells high amounts of human …