Recent advances in the design and discovery of synthetic tyrosinase inhibitors
J Li, L Feng, L Liu, F Wang, L Ouyang, L Zhang… - European Journal of …, 2021 - Elsevier
Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
Recent advances in triazoles as tyrosinase inhibitors
A Mermer, S Demirci - European Journal of Medicinal Chemistry, 2023 - Elsevier
The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a
significant position in melanogenesis, plays an important role in undesirable browning of …
significant position in melanogenesis, plays an important role in undesirable browning of …
Anti-melanogenesis and anti-tyrosinase properties of aryl-substituted acetamides of phenoxy methyl triazole conjugated with thiosemicarbazide: Design, synthesis …
H Hosseinpoor, SM Farid, A Iraji, MS Asgari… - Bioorganic …, 2021 - Elsevier
A series of aryl phenoxy methyl triazole conjugated with thiosemicarbazides were designed,
synthesized, and evaluated for their tyrosinase inhibitory activities in the presence of l-dopa …
synthesized, and evaluated for their tyrosinase inhibitory activities in the presence of l-dopa …
Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties
In the present study, a series of aryl-substituted thioqunoline conjugated to
thiosemicarbazide were rationally designed and synthesized. The formation of target …
thiosemicarbazide were rationally designed and synthesized. The formation of target …
Evaluating the effects of disubstituted 3-hydroxy-1H-pyrrol-2 (5H)-one analog as novel tyrosinase inhibitors
In the present study, a series of 3-hydroxy-1H-pyrrol-2 (5H)-one derivative were rationally
designed and synthesized. The structure of targeted compounds was confirmed by IR, 1 H …
designed and synthesized. The structure of targeted compounds was confirmed by IR, 1 H …
Design, synthesis, and biological evaluation of symmetrical azine derivatives as novel tyrosinase inhibitors
A series of symmetrical azine derivatives containing different substituted benzyl moieties
were designed, synthesized, and evaluated for their inhibitory activity against tyrosinase …
were designed, synthesized, and evaluated for their inhibitory activity against tyrosinase …
Synthesis and Evaluation of Antiproliferative Activity, Topoisomerase IIα Inhibition, DNA Binding and Non-Clinical Toxicity of New Acridine–Thiosemicarbazone …
G Sousa, MCF de Almeida, LL Lócio, VL Dos Santos… - Pharmaceuticals, 2022 - mdpi.com
In this study, we report the synthesis of twenty new acridine–thiosemicarbazone derivatives
and their antiproliferative activities. Mechanisms of action such as the inhibition of …
and their antiproliferative activities. Mechanisms of action such as the inhibition of …
Design, synthesis, spectroscopic characterization, in vitro tyrosinase inhibition, antioxidant evaluation, in silico and kinetic studies of substituted indole …
A Iraji, N Sheikhi, M Attarroshan, GRS Ardani… - Bioorganic …, 2022 - Elsevier
In the current study, twenty-five indole-carbohydrazide derivatives linked to different aryl
substitutions were rationally designed and synthesized. The structures of all derivatives …
substitutions were rationally designed and synthesized. The structures of all derivatives …
Rational Design, Synthesis, in Vitro, and in Silico Studies of Chlorophenylquinazolin‐4(3H)‐One Containing Different Aryl Acetohydrazides as Tyrosinase Inhibitors
M Hajimiri, M Khosravikia… - Chemistry & …, 2022 - Wiley Online Library
Tyrosinase plays a pivotal role in the hyperpigmentation and enzymatic browning of fruit and
vegetable. Therefore, tyrosinase inhibitors can be of interest in industries as depigmentation …
vegetable. Therefore, tyrosinase inhibitors can be of interest in industries as depigmentation …
Design, synthesis, biological evaluation, and molecular docking study of thioxo-2, 3-dihydroquinazolinone derivative as tyrosinase inhibitors
N Sepehri, M Khoshneviszadeh, SM Farid… - Journal of Molecular …, 2022 - Elsevier
Tyrosinase is known to be a key enzyme in melanogenesis and hyperpigmentation. In this
study, a series of thioxo-dihydroquinazolinone compounds were designed and synthesized …
study, a series of thioxo-dihydroquinazolinone compounds were designed and synthesized …