Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

Summary α2δ-1, commonly known as a voltage-activated Ca 2+ channel subunit, is a
binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is …

Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

The gabapentinoid drugs gabapentin and pregabalin are key front‐line therapies for various
neuropathies of peripheral and central origin. Originally designed as analogs of GABA, the …

The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …

Introduction: The first two alpha2delta ligands–gabapentin (GBP) and pregabalin (PGB)–
were initially synthesized as antiepileptics; however, they were later also found to be useful …

Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together,
except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which …

Neuropathic pain is a challenging clinical problem and remains difficult to treat. Altered gene
expression in peripheral sensory nerves and neurons due to nerve injury is well …

Voltage-gated calcium channels are thought to exist in the plasma membrane as
heteromeric proteins, in which the α1 subunit is associated with two auxiliary subunits, the …