Simple Summary The central nervous system constitutes a unique microenvironment to
which access is highly restricted. However, immune cells enter as part of their normal routine …

Background The cerebrospinal fluid (CSF) proteome could offer important insights into
central nervous system (CNS) malignancies. To advance proteomic research in pediatric …

The cerebrospinal fluid (CSF) is a key matrix for discovery of biomarkers relevant for
prognosis and the development of therapeutic targets in pediatric central nervous system …

Despite significant improvements in therapy, outcomes for childhood and young persons
with T-cell acute lymphoblastic leukemia (T-ALL) remain inferior compared with those with B …

Background Rearrangements of the histone‐lysine‐N‐methyltransferase (KMT2A),
previously referred to as mixed‐lineage leukemia (MLL), are among the most common …

Cure rates for patients with acute lymphoblastic leukemia (ALL) have improved markedly in
recent decades, in part due to risk stratification incorporating leukemia genomics, response …

Current intensified chemotherapy regimens have significantly increased survival rates for
pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL), but these treatments can …

Acute lymphocytic leukemia (ALL) is a commonly diagnosed cancer in children. Despite
technological advancements to improve treatment and survival rates, there has been a …

Acute lymphoblastic leukemia (ALL) is the most common cancer in children and one of the
success stories in cancer therapeutics. Risk-directed therapy based on clinical, biologic and …

Despite remarkable improvements in the survival of pediatric acute lymphoblastic leukemia
(ALL), sensitive detection and clinical management of central nervous system leukemia …