Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …

Oncolytic viruses (OVs) provide novel and promising therapeutic options for patients with
cancers resistant to traditional therapies. Natural or genetically modified OVs are …

The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Tumors are composed of different types of cancer cells that contribute to tumor
heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an …

Nanomedicine research has advanced dramatically in recent decades. Nonetheless,
traditional nanomedicine faces significant obstacles such as the low concentration of the …

Owing to the diversity and ease of preparation of nanomaterials, the rational nanocarriers
with a rational design have become increasingly popular in medical researches. Although …

Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the
formation and development of cancer cells. It plays a central role in three cyclic processes …

Changyong Gao, Zhihua Lin, Beatriz Jurado-Sánchez, Xiankun Lin, Zhiguang Wu,* and
Qiang He* drug-loaded nanoparticles with inherent tumoritropic property is an interesting …

Synthetic carriers such as polymer and lipid particles often struggle to meet clinical
expectations. Natural particulates—that range from pathogens to mammalian cells—are …

When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …