The structure and function of acylglycerophosphate acyltransferase 4/lysophosphatidic acid acyltransferase delta (AGPAT4/LPAATδ)

MA Zhukovsky, A Filograna, A Luini, D Corda… - Frontiers in Cell and …, 2019 - frontiersin.org
Lipid-modifying enzymes serve crucial roles in cellular processes such as signal
transduction (producing lipid-derived second messengers), intracellular membrane transport …

Gut metabolite L-lactate supports Campylobacter jejuni population expansion during acute infection

R Sinha, RM LeVeque, SM Callahan… - Proceedings of the …, 2024 - National Acad Sciences
How the microaerobic pathogen Campylobacter jejuni establishes its niche and expands in
the gut lumen during infection is poorly understood. Using 6-wk-old ferrets as a natural …

Components of the CtBP1/BARS-dependent fission machinery

C Valente, A Luini, D Corda - Histochemistry and cell biology, 2013 - Springer
The brefeldin A ADP-ribosylated substrate, a member of the C-terminal-binding protein
family that is referred to as CtBP1/BARS, is a dual-function protein that acts as a …

Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ

A Pagliuso, C Valente, LL Giordano, A Filograna… - Nature …, 2016 - nature.com
Membrane fission is an essential cellular process by which continuous membranes split into
separate parts. We have previously identified CtBP1-S/BARS (BARS) as a key component of …

Assembly of human C-terminal binding protein (CtBP) into tetramers

AG Bellesis, AM Jecrois, JA Hayes, CA Schiffer… - Journal of Biological …, 2018 - ASBMB
C-terminal binding protein 1 (CtBP1) and CtBP2 are transcriptional coregulators that repress
numerous cellular processes, such as apoptosis, by binding transcription factors and …

The oligomeric state of CtBP determines its role as a transcriptional co‐activator and co‐repressor of Wingless targets

C Bhambhani, JL Chang, DL Akey… - The EMBO journal, 2011 - embopress.org
C‐terminal‐binding protein (CtBP) is a well‐characterized transcriptional co‐repressor that
requires homo‐dimerization for its activity. CtBP can both repress and activate Wingless …

ANGUSTIFOLIA, a plant homolog of CtBP/BARS localizes to stress granules and regulates their formation

H Bhasin, M Hülskamp - Frontiers in plant science, 2017 - frontiersin.org
The ANGUSTIFOLIA (AN) gene in Arabidopsis is important for a plethora of morphological
phenotypes. Recently, AN was also reported to be involved in responses to biotic and …

Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells

A Filograna, S De Tito, ML Monte, R Oliva… - Journal of Experimental …, 2024 - Springer
Background The C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate
(CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor and as a fission …

Nicotinamide adenine dinucleotide-induced multimerization of the co-repressor CtBP1 relies on a switching tryptophan

DL Madison, JA Wirz, D Siess, JR Lundblad - Journal of Biological …, 2013 - ASBMB
The transcriptional co-repressor C-terminal binding protein (CtBP) interacts with a number of
repressor proteins and chromatin modifying enzymes. How the biochemical properties …

Cryo-EM structure of CtBP2 confirms tetrameric architecture

AM Jecrois, MM Dcona, X Deng, D Bandyopadhyay… - Structure, 2021 - cell.com
C-terminal binding proteins 1 and 2 (CtBP1 and CtBP2) are transcriptional regulators that
activate or repress many genes involved in cellular development, apoptosis, and metastasis …