Targeting strategies for tissue-specific drug delivery

Z Zhao, A Ukidve, J Kim, S Mitragotri - Cell, 2020 - cell.com
Off-target effects of systemically administered drugs have been a major hurdle in designing
therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to …

Advances in drug delivery systems based on red blood cells and their membrane-derived nanoparticles

PHD Nguyen, MK Jayasinghe, AH Le, B Peng… - ACS nano, 2023 - ACS Publications
Red blood cells (RBCs) and RBC membrane-derived nanoparticles have been historically
developed as bioinspired drug delivery systems to combat the issues of premature …

Engineering cells for precision drug delivery: New advances, clinical translation, and emerging strategies

CJ Chao, E Zhang, Z Zhao - Advanced Drug Delivery Reviews, 2023 - Elsevier
Cells have emerged as a promising new form of drug delivery carriers owing to their
distinguished advantages such as naturally bypassing immune recognition, intrinsic …

Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery

TC Pham, MK Jayasinghe, TT Pham… - Journal of …, 2021 - Wiley Online Library
Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable
biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting …

Reprogramming mitochondrial metabolism in synovial macrophages of early osteoarthritis by a camouflaged meta‐defensome

L Zhang, X Chen, P Cai, H Sun, S Shen… - Advanced …, 2022 - Wiley Online Library
Osteoarthritis (OA) is a low‐grade inflammatory and progressive joint disease, and its
progression is closely associated with an imbalance in M1/M2 synovial macrophages …

Antigen-specific therapeutic approaches for autoimmunity

P Serra, P Santamaria - Nature biotechnology, 2019 - nature.com
The main function of the immune system in health is to protect the host from infection by
microbes and parasites. Because immune responses to nonself bear the risk of unleashing …

Red blood cell hitchhiking: a novel approach for vascular delivery of nanocarriers

JS Brenner, S Mitragotri… - Annual review of …, 2021 - annualreviews.org
Red blood cell (RBC) hitchhiking is a method of drug delivery that can increase drug
concentration in target organs by orders of magnitude. In RBC hitchhiking, drug-loaded …

Induction of tolerance and immunity by dendritic cells: mechanisms and clinical applications

J Fucikova, L Palova-Jelinkova, J Bartunkova… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DCs) are key regulators of immune responses that operate at the interface
between innate and adaptive immunity, and defects in DC functions contribute to the …

Red blood cells as smart delivery systems

X Han, C Wang, Z Liu - Bioconjugate chemistry, 2018 - ACS Publications
Red blood cells (RBCs), also called erythrocytes, are the most abundant type of blood cells.
Recently, RBCs have been extensively studied as drug delivery systems because of their …

The role of protein corona on nanodrugs for organ-targeting and its prospects of application

S Wang, J Zhang, H Zhou, YC Lu, X Jin, L Luo… - Journal of Controlled …, 2023 - Elsevier
Nowadays, nanodrugs become a hotspot in the high-end medical field. They have the ability
to deliver drugs to reach their destination more effectively due to their unique properties and …