Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Epigenetic regulation of aging: implications for interventions of aging and diseases

K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Epigenetic clock: A promising biomarker and practical tool in aging

R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Aging hallmarks and the role of oxidative stress

E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

[HTML][HTML] Stress, diet, exercise: common environmental factors and their impact on epigenetic age

F Galkin, O Kovalchuk, D Koldasbayeva… - Ageing Research …, 2023 - Elsevier
Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …

Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

B Zhang, DE Lee, A Trapp, A Tyshkovskiy, AT Lu… - Nature Aging, 2023 - nature.com
Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across
several mouse tissues. However, its impact on biological age and long-term health is …

Human age reversal: Fact or fiction?

AA Johnson, BW English, MN Shokhirev… - Aging …, 2022 - Wiley Online Library
Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …

Biomarkers of aging for the identification and evaluation of longevity interventions

M Moqri, C Herzog, JR Poganik, J Justice, DW Belsky… - Cell, 2023 - cell.com
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

[HTML][HTML] The epigenetic aging, obesity, and lifestyle

M Franzago, L Pilenzi, S Di Rado… - Frontiers in Cell and …, 2022 - frontiersin.org
The prevalence of obesity has dramatically increased worldwide over the past decades.
Aging-related chronic conditions, such as type 2 diabetes and cardiovascular disease, are …

Looking for the philosopher's stone: Emerging approaches to target the hallmarks of aging in the skin

JM Lemaitre - Journal of the European Academy of …, 2024 - Wiley Online Library
Senescence and epigenetic alterations are two important hallmarks of cellular aging. During
aging, cells subjected to stress undergo many cycles of damage and repair before finally …