The biology, function, and biomedical applications of exosomes
BACKGROUND All cells, prokaryotes and eukaryotes, release extracellular vesicles (EVs)
as part of their normal physiology and during acquired abnormalities. EVs can be broadly …
as part of their normal physiology and during acquired abnormalities. EVs can be broadly …
[HTML][HTML] Exosome nanovesicles: a potential carrier for therapeutic delivery
Exosomes are small nanosized biovesicles that form when multivesicular bodies and the
plasma membrane fuse and are released into the surrounding body fluids. They are best …
plasma membrane fuse and are released into the surrounding body fluids. They are best …
Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis
Milk-derived extracellular vesicles (mEVs) have been proposed as a potential nanomedicine
for intestinal disorders; however, their impact on intestinal barrier integrity in gut …
for intestinal disorders; however, their impact on intestinal barrier integrity in gut …
High-quality milk exosomes as oral drug delivery system
J Zhong, B Xia, S Shan, A Zheng, S Zhang, J Chen… - Biomaterials, 2021 - Elsevier
Many drugs must be administered intravenously instead of oral administration due to their
poor oral bioavailability. The cost of repeated infusion treatment for 6 weeks every year is as …
poor oral bioavailability. The cost of repeated infusion treatment for 6 weeks every year is as …
Mother's milk: a purposeful contribution to the development of the infant microbiota and immunity
K Le Doare, B Holder, A Bassett… - Frontiers in …, 2018 - frontiersin.org
Breast milk is the perfect nutrition for infants, a result of millions of years of evolution. In
addition to providing a source of nutrition, breast milk contains a diverse array of microbiota …
addition to providing a source of nutrition, breast milk contains a diverse array of microbiota …
Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns
Exosomes participate in cell-to-cell communication, facilitated by the transfer of RNAs,
proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not …
proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not …
Exosome-derived microRNAs of human milk and their effects on infant health and development
BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …
development. Milk provides a wide spectrum of mammary epithelial cell-derived …
Human milk exosomes and their microRNAs survive digestion in vitro and are taken up by human intestinal cells
Scope Human milk exosomes provide a natural means of genetic material transfer to infants;
however, the effect of gastric/pancreatic digestion milk exosomes stability and their …
however, the effect of gastric/pancreatic digestion milk exosomes stability and their …
Extracellular vesicles—connecting kingdoms
E Woith, G Fuhrmann, MF Melzig - International journal of molecular …, 2019 - mdpi.com
It is known that extracellular vesicles (EVs) are shed from cells of almost every type of cell or
organism, showing their ubiquity in all empires of life. EVs are defined as naturally released …
organism, showing their ubiquity in all empires of life. EVs are defined as naturally released …
[HTML][HTML] Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants
Extracellular vesicles (EVs) in milk harbor a variety of compounds, including lipids, proteins,
noncoding RNAs, and mRNAs. Among the various classes of EVs, exosomes are of …
noncoding RNAs, and mRNAs. Among the various classes of EVs, exosomes are of …