Cirrhosis-associated immune dysfunction

A Albillos, R Martin-Mateos, S Van der Merwe… - Nature Reviews …, 2022 - nature.com
The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …

COVID-19 and corticosteroids: a narrative review

G El-Saber Batiha, AI Al-Gareeb, HM Saad… - …, 2022 - Springer
It has been reported that corticosteroid therapy was effective in the management of severe
acute respiratory syndrome (SARS) and the Middle East Respiratory Syndrome (MERS) …

Prognostic implications of neutrophil‐lymphocyte ratio in COVID‐19

S Jimeno, PS Ventura, JM Castellano… - European journal of …, 2021 - Wiley Online Library
Background The clinical presentation of COVID‐19 ranges from a mild, self‐limiting disease,
to multiple organ failure and death. Most severe COVID‐19 cases present low lymphocytes …

Neutrophil extracellular traps contribute to liver damage and increase defective low-density neutrophils in alcohol-associated hepatitis

Y Cho, TN Bukong, D Tornai, M Babuta, IS Vlachos… - Journal of …, 2023 - Elsevier
Background & Aims In alcohol-associated hepatitis (AH), inflammation and neutrophil counts
correlate with poor clinical outcomes. Here, we investigated how neutrophils contribute to …

Predictive value of the neutrophil to lymphocyte ratio for disease deterioration and serious adverse outcomes in patients with COVID-19: a prospective cohort study

ZY Zeng, SD Feng, GP Chen, JN Wu - BMC Infectious Diseases, 2021 - Springer
Background Early identification of patients who are at high risk of poor clinical outcomes is of
great importance in saving the lives of patients with novel coronavirus disease 2019 (COVID …

Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19

S Velazquez, R Madurga, JM Castellano… - BMC emergency …, 2021 - Springer
Background The vast impact of COVID-19 call for the identification of clinical parameter that
can help predict a torpid evolution. Among these, endothelial injury has been proposed as …

Research methodologies to address clinical unmet needs and challenges in alcohol‐associated liver disease

AK Singal, P Kwo, A Kwong, S Liangpunsakul… - …, 2022 - Wiley Online Library
Alcohol‐associated liver disease (ALD) is emerging worldwide as the leading cause of liver‐
related morbidity, mortality, and indication for liver transplantation. The ALD Special Interest …

Precision medicine and drug optimization in adult inflammatory bowel disease patients

S Vieujean, E Louis - Therapeutic Advances in …, 2023 - journals.sagepub.com
Inflammatory bowel diseases (IBD) encompass two main entities including ulcerative colitis
and Crohn's disease. Although having a common global pathophysiological mechanism …

[HTML][HTML] The role of neutrophils in alcohol-related hepatitis

RS Khan, PF Lalor, M Thursz, PN Newsome - Journal of Hepatology, 2023 - Elsevier
Alcohol-related liver disease is a major cause of liver disease-associated mortality, with
inpatient care being a major contributor to its clinical and economic burden. Alcohol-related …

Risk score for predicting in-hospital mortality in COVID-19 (rim score)

A López-Escobar, R Madurga, JM Castellano… - Diagnostics, 2021 - mdpi.com
Infection by SARS-CoV2 has devastating consequences on health care systems. It is a
global health priority to identify patients at risk of fatal outcomes. 1955 patients admitted to …