Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

A number of human diseases stem from defective genes. One approach to treating such
diseases is to replace, or override, the defective genes with normal genes, an approach …

We have demonstrated previously the oncolytic effects of a systemically delivered,
replicating vaccinia virus. To enhance the tumor specificity of this vector, we have developed …

Replication-defective recombinant adenovirus (Ad) vectors are under development for a
wide variety of gene therapy indications. A potential limiting factor associated with virus …

Persistence of adenovirus type 5 in blood has implications for the pathogenicity of the virus
infection and for the use of this virus in oncolysis and gene therapy. In this study, the kinetics …

Last-generation adenovirus vectors, also called helper-dependent or gutless adenovirus,
are very attractive for gene therapy because the associated in vivo immune response is …

Gene therapy promises to revolutionize medicine by treating the causes of disease rather
than the symptoms. We are nearing the end of the first decade of gene therapy, and this …

Adenoviral (Ad) vectors have emerged as a promising gene delivery platform for a variety of
therapeutic and vaccine purposes during last two decades. However, the presence of …

Adenovirus is a widely used vector for cancer gene therapy because of its high infection
efficiency and capacity for transgene expression in both dividing and nondividing cells …

Abstract The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly
pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several …