Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …

Presently, obesity is one of the major health problems in the developed as well as
developing countries due to lack of physical work and increasing sedentary life style …

Purpose In the present study we characterized a series of synthetic cannabinoids containing
various heterocyclic scaffolds that had been identified as constituents of “Spice”, a …

Monoamine Oxidase B is considered a successful target for developing antiparkinsonian
drugs. Due to the side effects of current MAO-B inhibitors, there's an urgent need for novel …

In recent years, many synthetic cannabinoid (CB) receptor agonists have appeared on the
market as constituents of herbal incense mixtures known as “spice”. Contrary to the declared …

Abstract Background In March and April 2018, more than 150 patients presented to hospitals
in Illinois with coagulopathy and bleeding diathesis. Area physicians and public health …

The orphan G-protein-coupled receptor GPR55, which is activated by 1-
lysophosphatidylinositol and interacts with cannabinoid (CB) receptor ligands, has been …

Cannabinoid receptors belong to the large family of G-protein-coupled receptors, which can
be divided into two receptor types, cannabinoid receptor type-1 (CB1) and cannabinoid …

GPR18 is a rhodopsin-like orphan G-protein-coupled receptor (GPCR) that is activated by
the natural cannabinoid (CB) Δ9-tetrahydrocannabinol (THC). It is highly expressed in …

Pharmacological treatment of psychiatric disorders remains challenging in clinical,
pharmacological, and scientific practice. Even if many different substances are established …