The role of microbiota-derived metabolites in colorectal cancer

C Duizer, MR de Zoete - International Journal of Molecular Sciences, 2023 - mdpi.com
The impact of bacterial members of the microbiota on the development of colorectal cancer
(CRC) has become clear in recent years. However, exactly how bacteria contribute to the …

FXR friend-ChIPs in the enterohepatic system

V Meadows, Z Yang, V Basaly… - Seminars in Liver …, 2023 - thieme-connect.com
Chronic liver diseases encompass a wide spectrum of hepatic maladies that often result in
cholestasis or altered bile acid secretion and regulation. Incidence and cost of care for many …

Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides

Y Wang, Y Yu, L Li, M Zheng, J Zhou, H Gong… - Nature …, 2023 - nature.com
Antimicrobial peptides (AMPs) are important mediators of intestinal immune surveillance.
However, the regional heterogeneity of AMPs and its regulatory mechanisms remain …

Insights into transport in mucus barrier: Exploring particle penetration through the intestinal mucus layer

M Valibeknejad, SM Abdoli, R Alizadeh… - Journal of Drug Delivery …, 2023 - Elsevier
Nearly all pharmaceuticals and nutrients must cross numerous barriers to gain access and
be eliminated from the body. The gastrointestinal mucosa, comprised of specialized …

Dietary cystine restriction increases the proliferative capacity of the small intestine of mice

JCW de Jong, KS van Rooijen, ECA Stigter… - Plos one, 2024 - journals.plos.org
Currently, over 88 million people are estimated to have adopted a vegan or vegetarian diet.
Cysteine is a semi-essential amino acid, which availability is largely dependent on dietary …

Intestinal barrier dysfunction in fatty liver disease: roles of microbiota, mucosal immune system, and bile acids

B Gupta, R Rai, M Oertel… - Seminars in liver disease, 2022 - thieme-connect.com
Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of progressive liver diseases
ranging from simple steatosis to steatohepatitis and fibrosis. Globally, NAFLD is the leading …

Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes

L Sun, L Wen, Q Li, R Chen, S Wen, X Lai, Z Lai, J Cao… - Nutrients, 2024 - mdpi.com
Black tea (BT), the most consumed tea worldwide, can alleviate hyperlipidemia which is a
serious threat to human health. However, the quality of summer BT is poor. It was improved …

Intestinal farnesoid X receptor modulates duodenal surface area but does not control glucose absorption in mice

J Yang, TH van Dijk, M Koehorst, R Havinga… - International Journal of …, 2023 - mdpi.com
Bile acids facilitate the intestinal absorption of dietary lipids and act as signalling molecules
in the maintenance of metabolic homeostasis. Farnesoid X receptor (FXR) is a bile acid …

A potential role for bile acid signaling in celiac disease-associated fatty liver

P Manka, S Sydor, JM Schänzer-Ocklenburg… - Metabolites, 2022 - mdpi.com
Celiac disease (CeD) is a chronic autoimmune disorder characterized by an intolerance to
storage proteins of many grains. CeD is frequently associated with liver damage and …

Analysis of strain, sex, and diet-dependent modulation of gut microbiota reveals candidate keystone organisms driving microbial diversity in response to American and …

AC Salvador, MN Huda, D Arends, AM Elsaadi… - Microbiome, 2023 - Springer
Background The gut microbiota is modulated by a combination of diet, host genetics, and
sex effects. The magnitude of these effects and interactions among them is important to …