Abstract Serotonin (5-HT) is known to play a critical role in regulation of essential neural
processes, whereas more recent research highlights serotonin's modulatory effects on …

The serotonergic precursor tryptophan and the dopaminergic precursor tyrosine have been
shown to be important modulators of mood, behaviour and cognition. Specifically, research …

Deficits in reward processing are a central feature of major depressive disorder with patients
exhibiting decreased reward learning and altered feedback sensitivity in probabilistic …

Psilocybin and its active metabolite psilocin are hallucinogenic serotonergic agonists with
high affinity for several serotonin receptors. In addition to underlying the hallucinogenic …

Background Alcohol use disorder is characterized by perseverative alcohol use despite
negative consequences. This hallmark feature of addiction potentially relates to impairments …

Central serotonin appears a promising transdiagnostic marker of psychiatric disorders and a
modulator of some of their key behavioral symptoms. In adult male Tph2−/− rats …

Cognitive flexibility refers to the mental processes that allow us to adapt our behaviour as
environmental circumstances change. In this paper, we describe various procedures that are …

Background Obesity has been linked to altered reward processing but little is known about
which components of reward processing including motivation, sensitivity and learning are …

Early life stress (ELS) is one of the biggest known risk factors for the development of a range
of psychiatric disorders including depression. Events exceeding a child's ability to cope lead …

Cognitive flexibility is the ability to adjust thinking and behavior based on changing
conditions. Cognitive rigidity has been described in a variety of psychiatric and …