Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …

Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …

Leucyl-tRNA synthetase (LeuRS) produces error-free leucyl-tRNALeu by coordinating
translocation of the 3′ end of (mis-) charged tRNAs from its synthetic site to a separate …

The recent development and spread of extensively drug-resistant and totally drug-resistant
resistant (TDR) strains of Mycobacterium tuberculosis highlight the need for new …

Aminoacyl-tRNA synthetases (aaRS) are the enzymes that ensure faithful transmission of
genetic information in all living cells, and are central to the developing technologies for …

The unique electron deficiency and coordination property of boron led to a wide range of
applications in chemistry, energy research, materials science and the life sciences. The use …

Leucyl-tRNA synthetase (LeuRS) specifically links leucine to the 3′ end of tRNAleu
isoacceptors. The overall accuracy of the two-step aminoacylation reaction is enhanced by …

The apicomplexan parasites Cryptosporidium and Toxoplasma are serious threats to human
health. Cryptosporidiosis is a severe diarrheal disease in malnourished children and …

Aminoacyl-tRNA synthetases (aaRSs) are modular enzymes globally conserved in the three
kingdoms of life. All catalyze the same two-step reaction, ie, the attachment of a …

Leucine‐rich repeat kinase 2 (LRRK2) is a causal gene of Parkinson disease. G2019S
pathogenic mutation increases its kinase activity. LRRK2 regulates various phenotypes …