The promise and challenge of high-throughput sequencing of the antibody repertoire
G Georgiou, GC Ippolito, J Beausang, CE Busse… - Nature …, 2014 - nature.com
Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid
organs using high-throughput DNA sequencing technologies have been advancing at an …
organs using high-throughput DNA sequencing technologies have been advancing at an …
Practical guidelines for B-cell receptor repertoire sequencing analysis
G Yaari, SH Kleinstein - Genome medicine, 2015 - Springer
High-throughput sequencing of B-cell immunoglobulin repertoires is increasingly being
applied to gain insights into the adaptive immune response in healthy individuals and in …
applied to gain insights into the adaptive immune response in healthy individuals and in …
Dysregulated naive B cells and de novo autoreactivity in severe COVID-19
MC Woodruff, RP Ramonell, NS Haddad, FA Anam… - Nature, 2022 - nature.com
Severe SARS-CoV-2 infection has been associated with highly inflammatory immune
activation since the earliest days of the COVID-19 pandemic,,–. More recently, these …
activation since the earliest days of the COVID-19 pandemic,,–. More recently, these …
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals
F Zhang, R Gan, Z Zhen, X Hu, X Li, F Zhou… - Signal transduction and …, 2020 - nature.com
The global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has
affected more than eight million people. There is an urgent need to investigate how the …
affected more than eight million people. There is an urgent need to investigate how the …
Tumor-reactive antibodies evolve from non-binding and autoreactive precursors
RD Mazor, N Nathan, A Gilboa, L Stoler-Barak, L Moss… - Cell, 2022 - cell.com
The tumor microenvironment hosts antibody-secreting cells (ASCs) associated with a
favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic …
favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic …
Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data
Advances in high-throughput sequencing technologies now allow for large-scale
characterization of B cell immunoglobulin (Ig) repertoires. The high germline and somatic …
characterization of B cell immunoglobulin (Ig) repertoires. The high germline and somatic …
Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications
Y Ye, Z Chen, S Jiang, F Jia, T Li, X Lu, J Xue… - Nature …, 2022 - nature.com
Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5+ DM) is
an autoimmune condition associated with rapidly progressive interstitial lung disease and …
an autoimmune condition associated with rapidly progressive interstitial lung disease and …
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …
B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV
Monoclonal antibodies (mAbs) are a focus in vaccine and therapeutic design to counteract
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. Here, we …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. Here, we …
pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires
Driven by dramatic technological improvements, large-scale characterization of lymphocyte
receptor repertoires via high-throughput sequencing is now feasible. Although promising …
receptor repertoires via high-throughput sequencing is now feasible. Although promising …