In December, 2019, reports emerged from Wuhan, China, of a severe acute respiratory
disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the …

Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …

The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Interleukins, a group of cytokines participating in inflammation and immune response, are
proved to be involved in the formation and development of pulmonary fibrosis. In this article …

Pulmonary fibrosis is a progressive inflammatory disease with high mortality and limited
therapeutic options. Previous genetic and immunologic investigations suggest common …

Successful recovery from lung injury requires the repair and regeneration of alveolar
epithelial cells to restore the integrity of gas-exchanging regions within the lung and …

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease with progressive fibrosis and
death within 2–3 y of diagnosis. IPF incidence and prevalence rates are increasing annually …

Rationale: Renal fibrosis is the terminal manifestation of chronic and irreversible renal
disease. Effective therapies other than dialysis are extremely limited. In this study, we …