During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

In addition to biochemical signals and genetic considerations, mechanical forces are rapidly
emerging as a master regulator of human physiology. However, the molecular mechanisms …

The emerging field of cultured meat faces several technical hurdles, including the scale-up
production of quality muscle and adipose progenitor cells, and the differentiation and …

Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …

Summary α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist
as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton …

Folding of stringent clients requires transfer from Hsp70 to Hsp90. The co-chaperone Hop
physically connects the chaperone machineries. Here, we define its role from the …

The glucocorticoid receptor (GR) is an important transcription factor and drug target linked to
a variety of biological functions and diseases. It is one of the most stringent physiological …

Cardiac muscle contraction is distinct from the contraction of other muscle types. The heart
continuously undergoes contraction–relaxation cycles throughout an animal's lifespan. It …

Abstract ACTN2 encodes alpha‐actinin‐2, a protein expressed in human cardiac and
skeletal muscle. The protein, located in the sarcomere Z‐disk, functions as a link between …