Distant metastasis accounts for the vast majority of deaths in patients with cancer. Breast
cancer exhibits a distinct metastatic pattern commonly involving bone, liver, lung, and brain …

Epithelial–mesenchymal transition (EMT) is a key step in transdifferentiation process in solid
cancer development. Forthcoming evidence suggest that the stratified program transforms …

Breast cancer arising at a young age is relatively uncommon, particularly in the developed
world. Several studies have demonstrated that younger patients often experience a more …

Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

Despite the advancement of treatment modalities, many cancer patients experience tumor
recurrence and metastasis at regional or distant sites. Evolving understanding of tumor …

The spread of cancer cells to distant organs represents a major clinical challenge in the
treatment of cancer. Epithelial–mesenchymal transition (EMT) has emerged as a key …

Evolutionarily conserved Notch plays a critical role in embryonic development and cellular
self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is …

The Notch signalling pathway is a highly conserved developmental signalling pathway, with
vital roles in determining cell fate during embryonic development and tissue homeostasis …

Breast cancer is the most common cancer in women and distant site metastasis is the main
cause of death in breast cancer patients. There is increasing evidence supporting the role of …

An abnormal multicellular architecture is a defining characteristic of breast cancer and, yet,
most in vitro tumor models fail to recapitulate this architecture or accurately predict in vivo …