Emerging rules for subunit-based, multiantigenic, multistage chemically synthesized vaccines

ME Patarroyo, MA Patarroyo - Accounts of chemical research, 2008 - ACS Publications
Seventeen million people die of transmittable diseases and 2/3 of the world's population
suffer them annually. Malaria, tuberculosis, AIDS, hepatitis, and reemerging and new …

Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development

ME Patarroyo, A Bermúdez, MA Patarroyo - Chemical reviews, 2011 - ACS Publications
Dedicated to the memory of Professors Henry G. Kunkel and Bruce Merrifield (Rockefeller
University, New York), who introduced us to the fascinating worlds of immunology and …

Structure of the Epstein-Barr virus major envelope glycoprotein

G Szakonyi, MG Klein, JP Hannan, KA Young… - Nature structural & …, 2006 - nature.com
Epstein-Barr virus (EBV) infection of B cells is associated with lymphoma and other human
cancers. EBV infection is initiated by the binding of the viral envelope glycoprotein (gp350) …

Cutting edge: Epstein-Barr virus transactivates the HERV-K18 superantigen by docking to the human complement receptor 2 (CD21) on primary B cells

FC Hsiao, M Lin, A Tai, G Chen… - The Journal of …, 2006 - journals.aai.org
EBV, a ubiquitous human herpesvirus, is the causative agent of infectious mononucleosis
and is associated with many carcinomas. We have previously shown that the EBV latent …

[HTML][HTML] A novel vaccine candidate based on chimeric virus-like particle displaying multiple conserved epitope peptides induced neutralizing antibodies against EBV …

X Zhang, B Zhao, M Ding, S Song, Y Kang, Y Yu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Rationale: Epstein-Barr virus (EBV) is the causative pathogen for infectious
mononucleosis and many kinds of malignancies including several lymphomas such as …

The structure-function relationships of complement receptor type 2 (CR2; CD21)

J Paul Hannan - Current Protein and Peptide Science, 2016 - ingentaconnect.com
Human complement receptor type 2 (CR2; CD21) is a surface-associated glycoprotein
which binds to a variety of endogenous ligands, including the complement component C3 …

Immunization with Fc-based recombinant Epstein–Barr virus gp350 elicits potent neutralizing humoral immune response in a BALB/c mice model

B Zhao, X Zhang, C Krummenacher, S Song… - Frontiers in …, 2018 - frontiersin.org
Epstein–Barr virus (EBV) was the first human virus proved to be closely associated with
tumor development, such as lymphoma, nasopharyngeal carcinoma, and EBV-associated …

High Epstein-Barr virus load and genomic diversity are associated with generation of gp350-specific neutralizing antibodies following acute infectious mononucleosis

ER Weiss, G Alter, JG Ogembo, JL Henderson… - Journal of …, 2017 - Am Soc Microbiol
ABSTRACT The Epstein-Barr virus (EBV) gp350 glycoprotein interacts with the cellular
receptor to mediate viral entry and is thought to be the major target for neutralizing …

Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350

KA Young, AP Herbert, PN Barlow, VM Holers… - Journal of …, 2008 - Am Soc Microbiol
The binding of the Epstein-Barr virus glycoprotein gp350 by complement receptor type 2
(CR2) is critical for viral attachment to B lymphocytes. We set out to test hypotheses …

Hepatitis B virus inhibits the expression of complement C3 and C4, in vitro and in vivo

C Zhu, H Song, F Xu, W Yi, F Liu… - Oncology …, 2018 - spandidos-publications.com
The immune system serves an important function in Hepatitis B virus (HBV) infection, and
the complement system is a major component of innate immunity. However, the regulatory …