It is widely accepted that nine hallmarks—including mitochondrial dysfunction, epigenetic
alterations, and loss of proteostasis—exist that describe the cellular aging process. Adding …

Age-related macular degeneration (AMD) is a progressive neurodegenerative disease
affecting the central area (macula lutea) of the retina. Research on the pathogenic …

Retinal degeneration (RD), a group of diseases leading to irreversible vision loss, is
characterised by retinal pigment epithelium (RPE) or retinal neuron damage and loss. With …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness
among the elderly, and there is currently no clinical treatment targeting the primary …

Age-related macular degeneration (AMD) is a complex disease caused by different genetic
and environmental risk factors leading to loss of cells in the central part of the retina …

Lipid processing by the retinal pigment epithelium (RPE) is necessary to maintain retinal
health and function. Dysregulation of retinal lipid homeostasis due to normal aging or age …

Retina is rich in lipids and dyslipidemia causes retinal dysfunction and eye diseases. In
retina, lipids are not only important membrane component in cells and organelles but also …

BACKGROUND: Retinal degenerative disease (RDD), one of the most common causes of
blindness, is predominantly caused by the gradual death of retinal pigment epithelial cells …

Age-related macular degeneration (AMD) is the leading cause of visual impairments and
blindness worldwide in the elderly and its incidence strongly increases with ages. The …

Drusen, the yellow deposits under the retina, are composed of lipids and proteins, and
represent a hallmark of age-related macular degeneration (AMD). Lipid droplets are also …