Proteases are an evolutionarily conserved family of enzymes that degrade peptide bonds
and have been implicated in several common gastrointestinal (GI) diseases. Although …

The GI tract is the most exposed organ to proteases, both in physiological and
pathophysiological conditions. For digestive purposes, the lumen of the upper GI tract …

Background & Aims Altered gut microbiota composition and function have been associated
with inflammatory bowel diseases, including ulcerative colitis (UC), but the causality and …

Antimicrobial peptides (AMP) are highly diverse and dynamic molecules that are expressed
by specific intestinal epithelial cells, Paneth cells, as well as immune cells in the …

The gut barrier plays an important role in human health. When barrier function is impaired,
altered permeability and barrier dysfunction can occur, leading to inflammatory bowel …

Elafin, a natural protease inhibitor expressed in healthy intestinal mucosa, has pleiotropic
anti-inflammatory properties in vitro and in animal models. We found that mucosal …

The resolution of inflammation is an active process orchestrated by specialized proresolving
lipid mediators (SPM) that limit the host response within the affected tissue; failure of …

The gastrointestinal barrier is-with approximately 400 m 2-the human body's largest surface
separating the external environment from the internal milieu. This barrier serves a dual …

Crohn's disease (CD) and ulcerative colitis (UC) are the two main forms of inflammatory
bowel disease (IBD). Among the various immune cells involved in IBD, neutrophils are the …

Highlights•Recombinant lactococci and lactobacilli have been successfully used in the last
years as safe mucosal delivery vectors for molecules of health interest.•The delivery of …