Ten years of anti-vascular endothelial growth factor therapy

N Ferrara, AP Adamis - Nature reviews Drug discovery, 2016 - nature.com
The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …

Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA)

U Schmidt-Erfurth, V Chong, A Loewenstein… - British Journal of …, 2014 - bjo.bmj.com
Age-related macular degeneration (AMD) is still referred to as the leading cause of severe
and irreversible visual loss world-wide. The disease has a profound effect on quality of life of …

Tolerating subretinal fluid in neovascular age-related macular degeneration treated with ranibizumab using a treat-and-extend regimen: FLUID study 24-month results

RH Guymer, CM Markey, IL McAllister, MC Gillies… - Ophthalmology, 2019 - Elsevier
Purpose To test the hypothesis that tolerating some subretinal fluid (SRF) in patients with
neovascular age-related macular degeneration (nAMD) treated with ranibizumab using a …

A paradigm shift in imaging biomarkers in neovascular age-related macular degeneration

U Schmidt-Erfurth, SM Waldstein - Progress in Retinal and eye Research, 2016 - Elsevier
Neovascular age-related macular degeneration (AMD) has undergone substantial break-
throughs in diagnostic as well as therapeutic respect, with optical coherence tomography …

[HTML][HTML] Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors

H Mehta, A Tufail, V Daien, AY Lee, V Nguyen… - Progress in retinal and …, 2018 - Elsevier
Clinical trials identified intravitreal vascular endothelial growth factor inhibitors (anti-VEGF
agents) have the potential to stabilise or even improve visual acuity outcomes in …

[HTML][HTML] Treat-and-extend versus monthly regimen in neovascular age-related macular degeneration: results with ranibizumab from the TREND study

R Silva, A Berta, M Larsen, W Macfadden, C Feller… - Ophthalmology, 2018 - Elsevier
Purpose To evaluate the efficacy and safety of ranibizumab 0.5 mg treat-and-extend (T&E)
versus monthly regimens in patients with neovascular age-related macular degeneration …

[HTML][HTML] Prospective trial of treat-and-extend versus monthly dosing for neovascular age-related macular degeneration: TREX-AMD 1-year results

CC Wykoff, DE Croft, DM Brown, R Wang, JF Payne… - Ophthalmology, 2015 - Elsevier
Purpose To assess prospectively a treat-and-extend (TREX) management strategy
compared with monthly dosing of intravitreal ranibizumab in treatment-naïve neovascular …

Treat-and-extend regimens with anti-VEGF agents in retinal diseases: a literature review and consensus recommendations

KB Freund, JF Korobelnik, R Devenyi, C Framme… - Retina, 2015 - journals.lww.com
Purpose: A review of treat-and-extend regimens (TERs) with intravitreal anti–vascular
endothelial growth factor agents in retinal diseases. Methods: There is a lack of consensus …

Long-term outcomes of treatment of neovascular age-related macular degeneration: data from an observational study

MC Gillies, A Campain, D Barthelmes, JM Simpson… - Ophthalmology, 2015 - Elsevier
Purpose To analyze the long-term outcomes of eyes with neovascular age-related macular
degeneration (AMD) starting treatment with vascular endothelial growth factor (VEGF) …

Metaanalysis of real-world outcomes of intravitreal ranibizumab for the treatment of neovascular age-related macular degeneration

LN Kim, H Mehta, D Barthelmes, V Nguyen, MC Gillies - Retina, 2016 - journals.lww.com
Purpose: To report the efficacy and safety of intravitreal ranibizumab for neovascular age-
related macular degeneration (nAMD) in real-world practice. Methods: Metaanalysis of∼ …