Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly
reduces lifespan, and its overexpression extends it and protects against various pathological …

The renal condition is one of the crucial predictors of longevity; therefore, early diagnosis of
any dysfunction plays an important role. Kidneys are highly susceptible to the aging process …

Cardiovascular disease is the leading cause of death worldwide. New therapeutic strategies
are aimed to modulate the athero-inflammatory process that partially orchestrates underlying …

Klotho is an identified longevity gene with beneficial pleiotropic effects on the kidney.
Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease …

Background and aim Klotho was first identified as a gene associated with aging and
longevity in 1997. α-Klotho is an anti-aging protein and its role in energy metabolism …

The effects of environmental factors and epigenetics on health and disease development
are complex and interconnected. Environmental factors encompass external influences like …

The actions of several bone-mineral ion regulators, namely PTH, FGF23, Klotho and 1, 25
(OH) 2 vitamin D (1, 25 (OH) 2D), control calcium and phosphate metabolism, and each of …

Introduction: Sepsis is a life-threatening inflammatory state that can result in septic acute
kidney injury (SAKI). Circular RNAs (circRNAs) are implicated in various inflammatory …

Acute kidney injury (AKI) is a collection of clinical syndromes with persistent increases in
morbidity and mortality rates. Hyperglycemia is a risk factor for AKI development. Renin …

Renal ischemia reperfusion injury (RIRI) is an inevitable complication during renal surgery.
Histone deacetylase 6 (HDAC6), a key member of the histone deacetylase family, is …