The thrifty phenotype hypothesis proposes that the epidemiological associations between
poor fetal and infant growth and the subsequent development of type 2 diabetes and the …

Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract,
remodel their apical surface during differentiation to form a brush border: an array of actin …

Mechanotransduction—a cell's conversion of a mechanical stimulus into an electrical signal—
reveals vital features of an organism's environment. From hair cells and skin …

We describe a novel mechanism for vital fluorescent dye entry into sensory cells and
neurons: permeation through ion channels. In addition to the slow conventional uptake of …

The role of the cochlea is to transduce complex sound waves into electrical neural activity in
the auditory nerve. Hair cells of the organ of Corti are the sensory cells of hearing. The inner …

Progressive hearing loss is common in the human population, but little is known about the
molecular basis. We report a new N-ethyl-N-nitrosurea (ENU)-induced mouse mutant …

Myosins are a large family of actin-based cytoskeletal motors that use energy derived from
ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have …

▪ Abstract Hereditary isolated hearing loss is genetically highly heterogeneous. Over 100
genes are predicted to cause this disorder in humans. Sixty loci have been reported and 24 …

Among the millions of invertebrate species with visual systems, the genetic basis of eye
development and function is well understood only in Drosophila melanogaster. We describe …