The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …

The ability of bacterial pathogens to invade host cells can have profound effects on the
establishment, persistence, and propagation of infections. By entering host cells and …

Congenital anomalies of the kidney and urinary tract (CAKUTs) represent the leading cause
of chronic kidney disease and end-stage kidney disease in children. Increasing evidence …

Urinary tract infections (UTI) are among the most prevalent infectious diseases and the most
common cause of nosocomial infections, worldwide. Uropathogenic E. coli (UPEC) are …

Repairing tubular tissues—the trachea, the esophagus, urinary and gastrointestinal tracts,
and the circulatory system—from trauma or severe pathologies that require resection, calls …

Most cases of congenital obstructive nephropathy are the result of ureteropelvic junction
obstructions, and despite their high prevalence, we have a poor understanding of their …

The primary function of the urinary bladder is to store and periodically release urine. How
the urothelium prevents permeation of water, ions, solutes, and noxious agents back into the …

Aim This review critically evaluates the evidence on mechanoreceptors and pathways in the
bladder urothelium that are involved in normal bladder filling signalling. Methods Evidence …

Urinary tract obstruction represents a common cause of kidney injury across the human life
span, resulting in chronic kidney disease and end-stage renal disease. Yet, the extent of …

Congenital urinary tract obstruction (UTO) is the leading cause of chronic kidney disease in
children; however, current management strategies do not safeguard against progression to …