NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the
immune system. Ligands of NKG2D are normally of low abundance, but can be induced in …

The field of immuno-oncology has revolutionized cancer patient care and improved survival
and quality of life for patients. Much of the focus in the field has been on exploiting the power …

Current efforts toward human immunodeficiency virus (HIV) eradication include approaches
to augment immune recognition and elimination of persistently infected cells following …

Natural killer (NK) cells are important effectors of innate immunity playing a key role in the
eradication and clearance of viral infections. Over the recent years, several studies have …

Interactions between the Fc segment of IgG and its receptors (FcγRs) found on cells such as
natural killer cells, monocytes, macrophages and neutrophils can potentially mediate …

Natural killer (NK) cells are innate cytolytic effectors that target HIV-infected CD4+ T cells. In
conjunction with antibodies recognizing the HIV envelope, NK cells also eliminate HIV …

A group of impressive immunotherapies for cancer treatment, including immune checkpoint-
blocking antibodies, gene therapy and immune cell adoptive cellular immunotherapy, have …

Simple Summary The immune system provides surveillance measures to identify and
remove damaged cell types at an early stage. One important example involves the NKG2D …

Simple Summary Natural Killer cells are known to eliminate tumors directly or via antibody
dependent cellular cytotoxicity. The complete modes and mechanisms of such killings are …

HIV-1 envelope glycoproteins (Env) represent the only virus-specific antigen exposed at the
surface of infected cells. In its unliganded form, Env from primary viruses samples a …