Background One of the major threats looming over the growing older population is frailty. It is
a distinctive health state characterised by increased vulnerability to internal and external …

Although the increased lifespan of our populations illustrates the success of modern
medicine, the risk of developing many diseases increases exponentially with old age …

abstract Objectives To perform a systematic review of neurologic involvement in Systemic
sclerosis (SSc) and Localized Scleroderma (LS), describing clinical features, neuroimaging …

Musculoskeletal (MSK) involvement of the hands is a significant source of morbidity,
impacting on quality of life in patients with systemic sclerosis (SSc). MSK complications are …

Epigenetic variations have been widely described to occur during the aging process. To
verify if these modifications are correlated with the inter-individual phenotypic variability of …

Ultrasound has been widely explored in systemic sclerosis in the clinical and research
settings. Ultrasound allows a non-invasive and ionising radiation-free 'window'into this …

Across the world, life expectancy is increasing. However, the years of life gained do not
always correspond to healthy life years, potentially leading to an increase in frailty. Given the …

Objectives To comparatively assess the sonographic spectrum of carpal tunnel syndrome
(CTS) in patients with rheumatoid arthritis (RA) and in patients with idiopathic CTS. Methods …

Peripheral neuropathy is associated with an increase in intraneural pressure, and hence
ultrasound elastography seems to be an ideal method to detect early stages of this condition …

Objective The epidemiology and treatment of peripheral neuropathy in systemic sclerosis
(SSc) is poorly understood. The objectives of this study were to evaluate the incidence …